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2.C.1.1.1
The TonB energy-transducing system. ExbB/D are listed under TC# 1.A.30.2.1. The rotational surveillance and energy transfer (ROSET) model of TonB action postulates a mechanism for the transfer of energy from the Inner Membrane to the Outer Membrane, triggering iron uptake and concentration in the periplasm (Klebba 2016).

Accession Number:P02929
Protein Name:TonB aka EXBA aka B1252
Length:239
Molecular Weight:26094.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Single-pass membrane protein2 / Periplasmic side3
Substrate Unknown

Cross database links:

Genevestigator: P02929
EchoBASE: EB1005
EcoGene: EG11012
DIP: DIP-48111N
RefSeq: AP_001878.1    NP_415768.1   
Entrez Gene ID: 945843   
Pfam: PF03544   
Drugbank: Drugbank Link   
BioCyc: EcoCyc:EG11012-MONOMER    ECOL168927:B1252-MONOMER   
KEGG: ecj:JW5195    eco:b1252   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030288 C:outer membrane-bounded periplasmic space
GO:0005886 C:plasma membrane
GO:0005381 F:iron ion transmembrane transporter activity
GO:0008565 F:protein transporter activity
GO:0043213 P:bacteriocin transport
GO:0015889 P:cobalamin transport
GO:0009597 P:detection of virus
GO:0046718 P:entry of virus into host cell
GO:0006826 P:iron ion transport

References (7)

[1] “DNA sequence of the Escherichia coli tonB gene.”  Postle K.et.al.   6310567
[2] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.”  Aiba H.et.al.   9097039
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Analysis of Escherichia coli TonB membrane topology by use of PhoA fusions.”  Roof S.K.et.al.   1885532
[6] “A sequence-specific function for the N-terminal signal-like sequence of the TonB protein.”  Karlsson M.et.al.   8316087
[7] “Crystal structure of the dimeric C-terminal domain of TonB reveals a novel fold.”  Chang C.et.al.   11328822
Structure:
1IHR   1QXX   1U07   1XX3   2GRX   2GSK     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTLDLPRRFP WPTLLSVCIH GAVVAGLLYT SVHQVIELPA PAQPISVTMV TPADLEPPQA 
61:	VQPPPEPVVE PEPEPEPIPE PPKEAPVVIE KPKPKPKPKP KPVKKVQEQP KRDVKPVESR 
121:	PASPFENTAP ARLTSSTATA ATSKPVTSVA SGPRALSRNQ PQYPARAQAL RIEGQVKVKF 
181:	DVTPDGRVDN VQILSAKPAN MFEREVKNAM RRWRYEPGKP GSGIVVNILF KINGTTEIQ