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3.A.1.106.15
Lipid flippase, PglK or WlaB, of 564 aas and 6 N-terminal TMSs with a C-terminal ATPase domain.  Mediates the ATP-dependent translocation of an undecaprenylpyrophosphate-linked heptasaccharide intermediate across the cell membrane, an essential step during the N-linked protein glycosylation pathway. Transport across the membrane is effected via ATP-driven conformation changes. Most likely, only the polar and charged part of the glycolipid enter the substrate-binding cavity, and the lipid tail remains exposed to the membrane lipids during the transmembrane flipping process (Alaimo et al. 2006; Kelly et al. 2006; Perez et al. 2015).

Accession Number:Q0P9C4
Protein Name:Protein glycosylation K
Length:564
Molecular Weight:64739.00
Species:Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) [192222]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate lipids

Cross database links:

Structure:
5c73     

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLKKLFFILS KEDKNFLFFL LVFSVFISFI ETFAISLVMP FITLASDFSY FDRNKYLISL 
61:	KEYLNIPVFE IIVYFGVGLI VFYVFRALLN AYYFHLLARF SKGRYHAIAY KVFSKFLNIN 
121:	YEKFTQKNQS EILKSITGEV YNLSTMISSF LLLMSEIFVV LLLYALMLLI NYKITLFLSI 
181:	FMVLNAFILV KILSPIIKKA GVRREEAMKN FFEILNTNLN NFKFIKLKTK EDGVLSLFKA 
241:	QSEAFSKANI TNESVAAVPR IYLEGIGFCV LVFIVVFLVL KNESDISGIL STISIFVLAL 
301:	YRLMPSANRI ITSYHDLLYY HSSLDIIYQN LRQEEENLGE EKLSFNQELK ICNLSFGYEG 
361:	KKYLFKNLNL NIKKGEKIAF IGESGCGKST LVDLIIGLLK PKEGQILIDE QELNANNTKN 
421:	YRQKIGYIPQ NIYLFNDSIA KNITFGDAVD EEKLNRVIKQ ANLEHFIKNL PQGVQTKVGD 
481:	GGSNLSGGQK QRIAIARALY LEPEMLVLDE ATSALDTQSE AKIMDEIYKI SKDKTMIIIA 
541:	HRLSTITQCD KVYRLEHGKL KEEK