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3.A.1.106.6
Multidrug efflux pump, Rv0194 (exports & causes resistance to ampicillin, streptomycin and chloramphenicol by 32- to 64-fold and to vancomycin and tetracycline by 4- to 8-fold (Danilchanka et al., 2008)).

Accession Number:O53645
Protein Name:Rv0194
Length:1194
Molecular Weight:129251.00
Species:Mycobacterium tuberculosis GN=Rv0194 PE=3 SV=1 [1773]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Virion1
Substrate Ampicillin, Streptomycin, Chloramphenicol, tetracycline, Vancomycin

Cross database links:

HEGENOM: HBG429047
RefSeq: NP_214708.1   
Entrez Gene ID: 886790   
Pfam: PF00664    PF00005   
KEGG: mtu:Rv0194   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (1)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MRTNCWWRLS GYVMRHRRDL LLGFGAALAG TVIAVLVPLV TKRVIDDAIA ADHRPLAPWA 
61:	VVLVAAAGAT YLLMYVRRYY GGRIAHLVQH DLRMDAFQAL LRWDGRQQDR WSSGQLIVRT 
121:	TNDLQLVQAL LFDVPNVLRH VLTLLLGVAV MTWLSVPLAL LAVLLVPVIG LIAHRSRRLL 
181:	AAATHCAQEH KAAVTGVVDA AVCGIRVVKA FGQEERETVK LVTASRALYA AQLRVARLNA 
241:	HFGPLLQTLP ALGQMAVFAL GGWMAAQGSI TVGTFVAFWA CLTLLARPAC DLAGMLTIAQ 
301:	QARAGAVRVL ELIDSRPTLV DGTKPLSPEA RLSLEFQRVS FGYVADRPVL REISLSVRAG 
361:	ETLAVVGAPG SGKSTLASLA TRCYDVTQGA VRIGGQDVRE LTLDSLRSAI GLVPEDAVLF 
421:	SGTIGANIAY GRPDATPEQI ATAARAAHIE EFVNTLPDGY QTAVGARGLT LSGGQRQRIA 
481:	LARALLHQPR LLIMDDPTSA VDAVIECGIQ EVLREAIADR TAVIFTRRRS MLTLADRVAV 
541:	LDSGRLLDVG TPDEVWERCP RYRELLSPAP DLADDLVVAE RSPVCRPVAG LGTKAAQHTN 
601:	VHNPGPHDHP PGPDPLRRLL REFRGPLALS LLLVAVQTCA GLLPPLLIRH GIDVGIRRHV 
661:	LSALWWAALA GTATVVIRWV VQWGSAMVAG YTGEQVLFRL RSVVFAHAQR LGLDAFEDDG 
721:	DAQIVTAVTA DVEAIVAFLR TGLVVAVISV VTLVGILVAL LAIRARLVLL IFTTMPVLAL 
781:	ATWQFRRASN WTYRRARHRL GTVTATLREY AAGLRIAQAF RAEYRGLQSY FAHSDDYRRL 
841:	GVRGQRLLAL YYPFVALLCS LATTLVLLDG AREVRAGVIS VGALVTYLLY IELLYTPIGE 
901:	LAQMFDDYQR AAVAAGRIRS LLSTRTPSSP AARPVGTLRG EVVFDAVHYS YRTREVPALA 
961:	GINLRIPAGQ TVVFVGSTGS GKSTLIKLVA RFYDPTHGTV RVDGCDLREF DVDGYRNRLG 
1021:	IVTQEQYVFA GTVRDAIAYG RPDATDAQVE RAAREVGAHP MITALDNGYL HQVTAGGRNL 
1081:	SAGQLQLLAL ARARLVDPDI LLLDEATVAL DPATEAVVQR ATLTLAARRT TLIVAHGLAI 
1141:	AEHADRIVVL EHGTVVEDGA HTELLAAGGH YSRLWAAHTR LCSPEITQLQ CIDA