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3.A.1.110.4
Alkaline protease exporter

Accession Number:Q03024
Protein Name:AprD aka PA1246
Length:593
Molecular Weight:63671.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Alkaline Proteases

Cross database links:

HEGENOM: HBG311207
RefSeq: NP_249937.1   
Entrez Gene ID: 881263   
Pfam: PF00664    PF00005   
BioCyc: PAER208964:PA1246-MONOMER   
KEGG: pae:PA1246   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0030256 C:type I protein secretion system complex
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0008565 F:protein transporter activity
GO:0030253 P:protein secretion by the type I secretion s...
GO:0055085 P:transmembrane transport

References (2)

[1] “Sequence of a cluster of genes controlling synthesis and secretion of alkaline protease in Pseudomonas aeruginosa: relationships to other secretory pathways.”  Duong F.et.al.   1427098
[2] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MARLGSSVTN EIKQALAASR GALRSVAAFS GVINLLMLVP SLYMLQVYDR VLSSANEVTL 
61:	LMLTLMALGV FVFMGALEAL RSFVLVRVSE RFDGQLHGRI YAAAFERNLR AGGQEASQAL 
121:	HDLTTLRQFI TGQALFAFFD APWFPVYLLV IFLFDPWLGL LSLVGALALM ALAWFNERAT 
181:	RAPLAKAGEL SIKSGQLASN NLRNAEVIEA MGMLGSMRGR WERLHQAFLD QQSLASERAA 
241:	RINALSKYLR IALQSLVLGL GAWLAVEGRI TPGMMIAGSI LMGRALGPID QLIGVWKQWG 
301:	AARDAYRRLS GLLDEFPARE RRMELPEPRG HLLLESLDAA PPGSEARTLR GLTLAIPAGS 
361:	VVGVIGPSGS GKSSLARVVL GIWPTLHGSV RLDGAEIRQY ERETLGPRIG YLPQDIELFA 
421:	GTVAENIARF GEVQADKVVE AARLAGVHEL VLRLPQGYDT VLGVGGAGLS GGQRQRIALA 
481:	RALYGAPTLV VLDEPNSNLD DSGEQALLAA IQALKARGCT VLLITHRAGV LGCADRLLAL 
541:	NAGQLHLYGE RDQVLAALNN QRAASASQQR ADYRVAGYGA PQVVAAPRQG GVE