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3.A.1.111.4
Bacteriocin immunity protein, SmbG (198 aas; 6TMSs in a 2+2+2 arrangement. (Exports bacteriocins and causes resistance to antibiotics such as tetracycline, penicillin and triclosan). Upregulated by exposure to antibiotics (Matsumoto-Nakano and Kuramitsu, 2006)

Accession Number:Q5TLL2
Protein Name:SmbG protein
Length:698
Molecular Weight:79106.00
Species:Streptococcus mutans [1309]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate tetracycline, Penicillin, Triclosan

Cross database links:

Pfam: PF00664    PF00005    PF03412   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0008233 F:peptidase activity
GO:0006508 P:proteolysis
GO:0055085 P:transmembrane transport

References (1)

[1] “Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5.”  Yonezawa H.et.al.   15673730

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSQTECGLCV AVMLMEYYDV RITLNDIPKE FSAGRDGTRI RGLKKIFDHF GFSMNMFKVT 
61:	DRLSEIKNSS LPGIAYRIGG HFVVVESISS NEVIILDPAF GRTKISKDEL DNDYKNLILK 
121:	ITPNENFKTV NTRGQEFSLI KEAVFFNKKL VVQVLIAAVI VYSLTLVAPL LLKGLVDNFL 
181:	VSKQIDTTIW ALSIGTIASS LVYFVVNRVK QITSIRLSIS VDKFLSKKVV DKLFKNKFEF 
241:	YLNRTSSDIQ YRLVLLKNLK TIISDIIIQT FLDIGSMVVI LIYIMNLQPL YAVFLAFITL 
301:	LVLSMSRFMR EKMLLYKNKE LATDSKLQVF QYDIFRAIFD VKVLGLSSKK HRSWHRYYED 
361:	YIKSHEKNQR FITLYQNILA YITLYVPIFI PILGIWISGL AHSNQVGTII SLQSITGTYI 
421:	SGLISIAQLS DNITTAKSYL IRIDDILLQE DEAVRNRTID FKGNIRVNNL SFVYPGAEDK 
481:	TLDDISFSIN EGESVAIVGE SGSGKSTLFY ILLGAYDNYE GDIYFEGLDL KILNKDALRE 
541:	QIGVVPQDAL LFNGSIKENL IEDFEVADND IYDALKKVTL LDFVYSLPMG INTVVSENGF 
601:	NFSGGQRQRL ALARAILNQK SMLFLDEATS ALDNITEHQI VEYLSEDSKT KIVIAHRLST 
661:	IKNSDKIIVL KDGQVSEVGD HHSLMAQKGE YYRMYSGK