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3.A.1.120.4
Carbomycin resistance ATPase (membrane constituent unknown)

Accession Number:Q60248
Protein Name:CarA
Length:551
Molecular Weight:60389.00
Species:Streptomyces thermotolerans [80858]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2
Substrate Caromycin

Cross database links:

Pfam: PF00005   

Gene Ontology

GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity

References (2)

[1] “Sequence similarity between macrolide-resistance determinants and ATP-binding transport proteins.”  Schoner B.et.al.   1612454
[2] “Nucleotide sequence analysis of the carbomycin biosynthetic genes including the 3-O-acyltransferase gene from Streptomyces thermotolerans.”  Arisawa A.et.al.   7772821

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTAQLALHD ITKRYQDHVV LDRIGFTIKP GEKVGVIGDN GSGKSTLIKL IAGREQPDNG 
61:	AVTVVAPGGV GYLAQTLELP LEATVQDAVD LALADLRELE EGMRRTEAEL AERPYQTGQD 
121:	PELAGLLESY AALVDRYQAR GGYEADSRVE IALHGLGLPG LERGRRLGTL SGGERSRLAL 
181:	AATLASEPEL LLLDEPTNDL DDRAVDWLEE HLRKHKGTVV AVTHDRLFLD RLTTTILEID 
241:	SGKVMRYGNG YEGYLAAKAA ERQRRLLEYE QWRAELDRSR DLIASNVARL DAIPRKLPFA 
301:	VFGAGQFRMR GRGHGAMVRI RNAKERVARL TENPVAPPPE PLTFTAEITT EAAQSRETVA 
361:	ELTGVRVGDR LSVDSLHLGP GERLLVTGPN GAGKTTLLRV LSGELEPDSG SLLVSGRVGH 
421:	LRQEQTPWRP GMTVLQAFSS GRAGDIDEHT EALLSLGLFS PDDLRQRVQD LSYGQRRRIE 
481:	LARLVTEPVD LLLLDEPTNH LSPALVEELE EALTGYQGTV VVVTHDRRMR SRFNGAHLTL 
541:	QDGRVAEFTA A