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3.A.1.204.1
Eye pigment precursor transporter, White.  Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. White dimerize with Brown for the transport of guanine. The Scarlet (TC# 3.A.1.204.17) and White complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules (Mackenzie et al. 2000).  The White and Scarlet proteins are located in the membranes of pigment granules within pigment cells and retinula cells of the compound eye.  Somatic knockouts of white in the noctuid moth, Helicoverpa armigera block pigmentation of the egg, first instar larva and adult eye, but germ-line knockouts of white are recessive lethal in the embryo (Khan et al. 2017).

Accession Number:P10090
Protein Name:WHIT aka W aka EG:BACN33B1.1 aka CG2759
Length:687
Molecular Weight:75673.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate guanine, 3-hydroxy kynurenine, pigment precursors

Cross database links:

eggNOG: inNOG04985
DIP: DIP-388N
RefSeq: NP_476787.1   
Entrez Gene ID: 31271   
Pfam: PF01061    PF00005   
KEGG: dme:Dmel_CG2759   

Gene Ontology

GO:0031410 C:cytoplasmic vesicle
GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0031409 F:pigment binding
GO:0004888 F:transmembrane receptor activity
GO:0042401 P:cellular biogenic amine biosynthetic process
GO:0070731 P:cGMP transport
GO:0048072 P:compound eye pigmentation
GO:0006856 P:eye pigment precursor transport
GO:0007613 P:memory
GO:0006727 P:ommochrome biosynthetic process

References (8)

[1] “Sequence of a cDNA from the Drosophila melanogaster white gene.”  Pepling M.et.al.   2109311
[2] “DNA sequence of the white locus of Drosophila melanogaster.”  O'Hare K.et.al.   6084717
[3] “Dual-tagging gene trap of novel genes in Drosophila melanogaster.”  Lukacsovich T.et.al.   11156992
[4] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[5] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[6] “From sequence to chromosome: the tip of the X chromosome of D. melanogaster.”  Benos P.V.et.al.   10731137
[7] “Cloning and characterization of the scarlet gene of Drosophila melanogaster.”  Tearle R.G.et.al.   2503416
[8] “Sub-cellular localisation of the white/scarlet ABC transporter to pigment granule membranes within the compound eye of Drosophila melanogaster.”  Mackenzie S.M.et.al.   11294610

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGQEDQELLI RGGSKHPSAE HLNNGDSGAA SQSCINQGFG QAKNYGTLLP PSPPEDSGSG 
61:	SGQLAENLTY AWHNMDIFGA VNQPGSGWRQ LVNRTRGLFC NERHIPAPRK HLLKNVCGVA 
121:	YPGELLAVMG SSGAGKTTLL NALAFRSPQG IQVSPSGMRL LNGQPVDAKE MQARCAYVQQ 
181:	DDLFIGSLTA REHLIFQAMV RMPRHLTYRQ RVARVDQVIQ ELSLSKCQHT IIGVPGRVKG 
241:	LSGGERKRLA FASEALTDPP LLICDEPTSG LDSFTAHSVV QVLKKLSQKG KTVILTIHQP 
301:	SSELFELFDK ILLMAEGRVA FLGTPSEAVD FFSYVGAQCP TNYNPADFYV QVLAVVPGRE 
361:	IESRDRIAKI CDNFAISKVA RDMEQLLATK NLEKPLEQPE NGYTYKATWF MQFRAVLWRS 
421:	WLSVLKEPLL VKVRLIQTTM VAILIGLIFL GQQLTQVGVM NINGAIFLFL TNMTFQNVFA 
481:	TINVFTSELP VFMREARSRL YRCDTYFLGK TIAELPLFLT VPLVFTAIAY PMIGLRAGVL 
541:	HFFNCLALVT LVANVSTSFG YLISCASSST SMALSVGPPV IIPFLLFGGF FLNSGSVPVY 
601:	LKWLSYLSWF RYANEGLLIN QWADVEPGEI SCTSSNTTCP SSGKVILETL NFSAADLPLD 
661:	YVGLAILIVS FRVLAYLALR LRARRKE