3.A.1.204.6 The efflux porter for phosphatidylcholine and its analogues as well as toxic alkyl phospholipids, ABCG4 (Castanys-Munoz et al., 2007). Also promotes cholesterol efflux to the mature forms of HDL (HDL2 and HDL3) (Voloshyna and Reiss, 2011).
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Accession Number: | A4HWI7 |
Protein Name: | ABCG4 |
Length: | 741 |
Molecular Weight: | 83045.00 |
Species: | Leishmania infantum [5671] |
Number of TMSs: | 5 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
Phosphatidylcholine, alkyl phospholipids, cholesterol |
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1: MGTQVDQAHK PSVGTPTELT SIPPTASVTP PQAKSNAEDA KVPALSRAVN FTWENLTYQV
61: PVEDKDGNVI YKTLLFNLSG CAKGGRVLAI MGPSGAGKTT LMGTITGKLF NATARQEGCC
121: FMNNNIYQQR YKRLVSYVCQ DDIVMGKDTP REAIYFSARL RLGLDSETAR RRVADVIKRL
181: SLTKCQDTIL GIPGILKGVS GGERKRANIG TELVTNPFVM LLDEPTTGLD SVNAVRVGHL
241: LQDLAKNDMR TVIATVHSPS SELFDLFDDL LLLAKGHVIY HGPTADSIEY FASLGYDVPP
301: RTNPTEYFMN LLQLPEEILS QLWLAWEDYV MSDAANDNPC LTPVTGVITL TDDYLEEQLE
361: LKGANFCLQF SELFKRSWRM YLRDPGNFYG RSVQTLFFAI FVGLFFFNLQ LNQQGVQDRL
421: GALYVTLMNN LFGAAMNGIA AFPPERAVFL QEQANDAYNA YTYFLAKNLA ELPWQILFPT
481: VFDLIAYFMI HFHRSAGAFF VHWFILVLLA NLGYSFGLMF ATFFKQSQAA FAMVPLILLP
541: LFIVAGLFAN TDRLYPYWEW LNYISFPRHA YLGVFTNEFE RLTVICDPVT PLCTFPDGQA
601: VIEYMGFQGW HYWQTFVALI VYQIGLRFIG ATSLYYQGRQ RRGKLQFVKN LRKRVASPRA
661: IASARSNDEL SDVQSTLVGS IATPSNAYGT GVSSPINNPE NHQPIWDGES ERATLALPDT
721: PVTYVESPVD VKDMKPRKYR S