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3.A.1.208.1
Multi-drug resistance-associated protein, MRP1-like protein (MLP1 or MRP1) (Exporter of leukotrienes, glutathione and cysteinyl conjugates of organic anions, drugs, unmodified hydrophobic xenobiotics and hydrophilic conjugated endobiotics). Vincristine and glutathione are co-transported. MRP1 catalyzes export of glutathione during apoptosis (Hammond et al., 2007). Also transports reduced folates as well as mono-, di- and tri-glutamate derivatives of folic acid and methotrexate (Assaraf et al., 2006).

Accession Number:O88269
Protein Name:MRP6 aka MRP1 aka MLP1 aka ABCC6
Length:1502
Molecular Weight:164995.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate drugs, Leukotrienes, Glutathione, Cysteinyl conjugates, Vincristine, Folates, methotrexate, Folate derivatives

Cross database links:

Genevestigator: O88269
eggNOG: maNOG12411
RefSeq: NP_112275.1   
Entrez Gene ID: 81642   
Pfam: PF00664    PF00005   
KEGG: rno:81642   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0016328 C:lateral plasma membrane
GO:0005624 C:membrane fraction
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006200 P:ATP catabolic process
GO:0055085 P:transmembrane transport

References (2)

[1] “Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.”  Hirohashi T.et.al.   9614210
[2] “Transport function and hepatocellular localization of mrp6 in rat liver.”  Madon J.et.al.   10692506

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNGEHSMATP GESCAGLRVW NQTEQEPVAY HLLNLCFLRA AGSWVPPMYL WVLGPIYLLY 
61:	IHRHGCCYLR MSRLFKIKMV LGFALILLYT FNAAVPLWRI HRGMPQAPEL LIHPTVWLTT 
121:	MSFATFLIHM ERKKGVRASG LLFGYWLLCC LVPAIDTVQQ ASAGSFRQEP LHHLATYLCL 
181:	SLVVAELVLS CLVDQPPFFS EDSKPLNPCP EAEASFPSKA MFWWASGLLW KGYRKLLGPK 
241:	DLWSLERENS SEELVSQLER EWRRNFSELP GHKGHSGMGT PETEAFLQPE RSQRGPLLRA 
301:	IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDL ESSAWTGWLL AVLMFLSACL 
361:	QTLFEQQYMY RVKVLQMRLR TAITGLVYRK VLVLSSGSRK SSAAGDVVNL VSVDVQRLVE 
421:	SILHLNGLWL LFLWIIVCFV YLWQLLGPSA LTAVAVFLSL LPLNFFITKK RSFHQEEQMR 
481:	QKASRARLTS SMLRTVRTIK SHGWECAFLE RLLHIRGQEL GALKTSAFLF SVSLVSFQVS 
541:	TFLVALVVFA VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCL VQARVSFDRL 
601:	AAFLCLEEVD PNGMVLSPSR CSSKDRISIH NGTFAWSQES PPCLHGINLT VPQGCLLAVV 
661:	GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV QNTSVVENVC FRQELDLPWL 
721:	QEVLEACALG SDVASFPAGV HTPVGEQGMN LSGGQKQRLS LARAVYRRAA VYLMDDPLAA 
781:	LDAHVSQEVF KQVIGPSGLL QGTTRILVTH TLHVLPQADQ ILVLANGTIA EMGSYQDLLH 
841:	RNGALVGLLD GARQPAGEGE GEAHAAATSD DLGGFSGGGT PTRRPERPRP SDAAPVKGST 
901:	SEAQMEPSLD DVEVTGLTAG EDSVQYGRVK SATYLSYLRA VGTPLCTYTL FLFLCQQVAS 
961:	FCQGYWLSLW ADDPVVDGKQ MHSALRGSIF GLLGCLQAIG LFASMAAVFL GGARASCLLF 
1021:	RSLLWDVARS PIGFFERTPV GNLLNRFSKE TDIVDVDIPD KMRTLLTYAF GLLEVGLAVS 
1081:	MATPLAIVAI LPLMLLYAGF QSLYVATCCQ LRRLESASYS SVCSHLAETF QGSQVVRAFQ 
1141:	AQGPFTAQHD ALMDENQRIS FPRLVADRWL AANLELLGNG LVFVAATCAV LSKAHLSAGL 
1201:	AGFSVSAALQ VTQTLQWVVR SWTDLENSMV AVERVQDYVH TPKEAPWRLP SSAAQPLWPC 
1261:	GGQIEFRDFG LRHRPELPMA VQGVSLKIHA GEKVGIVGRT GAGKSSLTWG LLRLQEATEG 
1321:	GIWIDGVPIT DMGLHTLRSR ITIIPQDPVL FPGSLRMNLD LLQENTDEGI WAALETVQLK 
1381:	AFVTSLPGQL QYECSGQGDD LSVGQKQLLC LARALLRKTQ ILILDEATAS VDPGTEIQMQ 
1441:	AALERWFAQC TVLLIAHRLR SVMNCARVLV MDEGQVAESG SPAQLLAQKG LFYRLAQESG 
1501:	LA