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3.A.1.208.21
The thale cress protein atMRP5 (atABCC5), a high-affinity inositol hexakisphosphate transporter; involved in guard cell signaling and phytate storage (Nagy et al., 2009). Transports organic anions and phytate (Lefèvre and Boutry 2018).

Accession Number:Q7GB25
Protein Name:ABC transporter C family member 5
Length:1514
Molecular Weight:168574.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:17
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Inositol hexakisphosphate

Cross database links:

Genevestigator: Q7GB25
eggNOG: KOG0054
HEGENOM: HBG758042
RefSeq: NP_171908.1   
Entrez Gene ID: 839277   
Pfam: PF00664    PF00005   
KEGG: ath:AT1G04120   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0000325 C:plant-type vacuole
GO:0005886 C:plasma membrane
GO:0005774 C:vacuolar membrane
GO:0005524 F:ATP binding
GO:0008281 F:sulfonylurea receptor activity
GO:0008559 F:xenobiotic-transporting ATPase activity
GO:0030007 P:cellular potassium ion homeostasis
GO:0009651 P:response to salt stress
GO:0055085 P:transmembrane transport

References (8)

[1] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[2] “The Arabidopsis thaliana ABC transporter AtMRP5 controls root development and stomata movement.”  Gaedeke N.et.al.   11296221
[3] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.”  Sanchez-Fernandez R.et.al.   11346655
[4] “Multifunctionality of plant ABC transporters -- more than just detoxifiers.”  Martinoia E.et.al.   11855639
[5] “Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana.”  Kolukisaoglu U.H.et.al.   12430019
[6] “The plant multidrug resistance ABC transporter AtMRP5 is involved in guard cell hormonal signalling and water use.”  Klein M.et.al.   12943546
[7] “Binding of sulfonylurea by AtMRP5, an Arabidopsis multidrug resistance-related protein that functions in salt tolerance.”  Lee E.K.et.al.   14684837
[8] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDFIEISLIF REHLPLLELC SVIINLLLFL VFLFAVSARQ ILVCVRRGRD RLSKDDTVSA 
61:	SNLSLEREVN HVSVGFGFNL SLLCCLYVLG VQVLVLVYDG VKVRREVSDW FVLCFPASQS 
121:	LAWFVLSFLV LHLKYKSSEK LPFLVRIWWF LAFSICLCTM YVDGRRLAIE GWSRCSSHVV 
181:	ANLAVTPALG FLCFLAWRGV SGIQVTRSSS DLQEPLLVEE EAACLKVTPY STAGLVSLIT 
241:	LSWLDPLLSA GSKRPLELKD IPLLAPRDRA KSSYKVLKSN WKRCKSENPS KPPSLARAIM 
301:	KSFWKEAACN AVFAGLNTLV SYVGPYLISY FVDYLGGKEI FPHEGYVLAG IFFTSKLIET 
361:	VTTRQWYMGV DILGMHVRSA LTAMVYRKGL KLSSIAKQNH TSGEIVNYMA VDVQRIGDYS 
421:	WYLHDIWMLP MQIVLALAIL YKSVGIAAVA TLVATIISIL VTIPLAKVQE DYQDKLMTAK 
481:	DERMRKTSEC LRNMRVLKLQ AWEDRYRVRL EEMREEEYGW LRKALYSQAF VTFIFWSSPI 
541:	FVAAVTFATS IFLGTQLTAG GVLSALATFR ILQEPLRNFP DLVSMMAQTK VSLDRISGFL 
601:	QEEELQEDAT VVIPRGLSNI AIEIKDGVFC WDPFSSRPTL SGIQMKVEKG MRVAVCGTVG 
661:	SGKSSFISCI LGEIPKISGE VRICGTTGYV SQSAWIQSGN IEENILFGSP MEKTKYKNVI 
721:	QACSLKKDIE LFSHGDQTII GERGINLSGG QKQRVQLARA LYQDADIYLL DDPFSALDAH 
781:	TGSDLFRDYI LSALAEKTVV FVTHQVEFLP AADLILVLKE GRIIQSGKYD DLLQAGTDFK 
841:	ALVSAHHEAI EAMDIPSPSS EDSDENPIRD SLVLHNPKSD VFENDIETLA KEVQEGGSAS 
901:	DLKAIKEKKK KAKRSRKKQL VQEEERVKGK VSMKVYLSYM GAAYKGALIP LIILAQAAFQ 
961:	FLQIASNWWM AWANPQTEGD ESKVDPTLLL IVYTALAFGS SVFIFVRAAL VATFGLAAAQ 
1021:	KLFLNMLRSV FRAPMSFFDS TPAGRILNRV SIDQSVVDLD IPFRLGGFAS TTIQLCGIVA 
1081:	VMTNVTWQVF LLVVPVAVAC FWMQKYYMAS SRELVRIVSI QKSPIIHLFG ESIAGAATIR 
1141:	GFGQEKRFIK RNLYLLDCFV RPFFCSIAAI EWLCLRMELL STLVFAFCMV LLVSFPHGTI 
1201:	DPSMAGLAVT YGLNLNGRLS RWILSFCKLE NKIISIERIY QYSQIVGEAP AIIEDFRPPS 
1261:	SWPATGTIEL VDVKVRYAEN LPTVLHGVSC VFPGGKKIGI VGRTGSGKST LIQALFRLIE 
1321:	PTAGKITIDN IDISQIGLHD LRSRLGIIPQ DPTLFEGTIR ANLDPLEEHS DDKIWEALDK 
1381:	SQLGDVVRGK DLKLDSPVLE NGDNWSVGQR QLVSLGRALL KQAKILVLDE ATASVDTATD 
1441:	NLIQKIIRTE FEDCTVCTIA HRIPTVIDSD LVLVLSDGRV AEFDTPARLL EDKSSMFLKL 
1501:	VTEYSSRSTG IPEL