TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.208.31
Multidrug resistance-associated protein 7, MRP7 or ABCC10 of 1492 aas. Probably involved in cellular detoxification through lipophilic anion extrusion. Isoform 1 is specifically expressed in spleen; isoform 2 is more widely expressed. The combination of ibrutinib and paclitaxel can effectively antagonize ABCB1- or ABCC10-mediated paclitaxel resistance (Zhang et al. 2017).

Accession Number:Q5T3U5
Protein Name:Multidrug resistance-associated protein 7
Length:1492
Molecular Weight:161629.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:17
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MERLLAQLCG SSAAWPLPLW EGDTTGHCFT QLVLSALPHA LLAVLSACYL GTPRSPDYIL 
61:	PCSPGWRLRL AASFLLSVFP LLDLLPVALP PGAGPGPIGL EVLAGCVAAV AWISHSLALW 
121:	VLAHSPHGHS RGPLALALVA LLPAPALVLT VLWHCQRGTL LPPLLPGPMA RLCLLILQLA 
181:	ALLAYALGWA APGGPREPWA QEPLLPEDQE PEVAEDGESW LSRFSYAWLA PLLARGACGE 
241:	LRQPQDICRL PHRLQPTYLA RVFQAHWQEG ARLWRALYGA FGRCYLALGL LKLVGTMLGF 
301:	SGPLLLSLLV GFLEEGQEPL SHGLLYALGL AGGAVLGAVL QNQYGYEVYK VTLQARGAVL 
361:	NILYCKALQL GPSRPPTGEA LNLLGTDSER LLNFAGSFHE AWGLPLQLAI TLYLLYQQVG 
421:	VAFVGGLILA LLLVPVNKVI ATRIMASNQE MLQHKDARVK LVTELLSGIR VIKFCGWEQA 
481:	LGARVEACRA RELGRLRVIK YLDAACVYLW AALPVVISIV IFITYVLMGH QLTATKVFTA 
541:	LALVRMLILP LNNFPWVING LLEAKVSLDR IQLFLDLPNH NPQAYYSPDP PAEPSTVLEL 
601:	HGALFSWDPV GTSLETFISH LEVKKGMLVG IVGKVGCGKS SLLAAIAGEL HRLRGHVAVR 
661:	GLSKGFGLAT QEPWIQFATI RDNILFGKTF DAQLYKEVLE ACALNDDLSI LPAGDQTEVG 
721:	EKGVTLSGGQ RARIALARAV YQEKELYLLD DPLAAVDADV ANHLLHRCIL GMLSYTTRLL 
781:	CTHRTEYLER ADAVLLMEAG RLIRAGPPSE ILPLVQAVPK AWAENGQESD SATAQSVQNP 
841:	EKTKEGLEEE QSTSGRLLQE ESKKEGAVAL HVYQAYWKAV GQGLALAILF SLLLMQATRN 
901:	AADWWLSHWI SQLKAENSSQ EAQPSTSPAS MGLFSPQLLL FSPGNLYIPV FPLPKAAPNG 
961:	SSDIRFYLTV YATIAGVNSL CTLLRAVLFA AGTLQAAATL HRRLLHRVLM APVTFFNATP 
1021:	TGRILNRFSS DVACADDSLP FILNILLANA AGLLGLLAVL GSGLPWLLLL LPPLSIMYYH 
1081:	VQRHYRASSR ELRRLGSLTL SPLYSHLADT LAGLSVLRAT GATYRFEEEN LRLLELNQRC 
1141:	QFATSATMQW LDIRLQLMGA AVVSAIAGIA LVQHQQGLAN PGLVGLSLSY ALSLTGLLSG 
1201:	LVSSFTQTEA MLVSVERLEE YTCDLPQEPQ GQPLQLGTGW LTQGGVEFQD VVLAYRPGLP 
1261:	NALDGVTFCV QPGEKLGIVG RTGSGKSSLL LVLFRLLEPS SGRVLLDGVD TSQLELAQLR 
1321:	SQLAIIPQEP FLFSGTVREN LDPQGLHKDR ALWQALKQCH LSEVITSMGG LDGELGEGGR 
1381:	SLSLGQRQLL CLARALLTDA KILCIDEATA SVDQKTDQLL QQTICKRFAN KTVLTIAHRL 
1441:	NTILNSDRVL VLQAGRVVEL DSPATLRNQP HSLFQQLLQS SQQGVPASLG GP