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3.A.1.208.5
Vacuolar multidrug resistance efflux pump, AtMRP2 (catalyzes vacuolar uptake of glutathione conjugates (i.e., 2,4-dinitrophenyl-GS), glucuronide conjugates (i.e., 17 β-estradiol 17(β-D-glucuronide), and reduced glutathione). Also exports the herbicide, 1-chloro-2, 4-dinitrobenzene, and chlorophyll degradation catabolites (Frelet-Barrand et al., 2008).

Accession Number:Q42093
Protein Name:ABC transporter C family member 2
Length:1623
Molecular Weight:182130.00
Species: [3702]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate drugs, Glutathione conjugates, 2,4-dinitrophenyl-GS, 17 beta-estradiol, Reduced glutathione, 1-chloro-2,4-dinitrobenzene, Chlorophyll catabolites

Cross database links:

Genevestigator: Q42093
eggNOG: KOG0054
HEGENOM: HBG758042
RefSeq: NP_181013.1   
Entrez Gene ID: 818031   
Pfam: PF00664    PF00005   
KEGG: ath:AT2G34660   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0000325 C:plant-type vacuole
GO:0005886 C:plasma membrane
GO:0005774 C:vacuolar membrane
GO:0005524 F:ATP binding
GO:0005516 F:calmodulin binding
GO:0008559 F:xenobiotic-transporting ATPase activity
GO:0055085 P:transmembrane transport

References (10)

[1] “Cloning of AtMRP1, an Arabidopsis thaliana cDNA encoding a homologue of the mammalian multidrug resistance-associated protein.”  Marin E.et.al.   9528668
[2] “AtMRP2, an Arabidopsis ATP-binding cassette transporter able to transport glutathione S-conjugates and chlorophyll catabolites: functional comparisons with AtMRP1.”  Lu Y.-P.et.al.   9490749
[3] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[4] “Differential expression of genes coding for ABC transporters after treatment of Arabidopsis thaliana with xenobiotics.”  Tommasini R.et.al.   9271206
[5] “Enhanced multispecificity of Arabidopsis vacuolar multidrug resistance-associated protein-type ATP-binding cassette transporter, AtMRP2.”  Liu G.et.al.   11115509
[6] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.”  Sanchez-Fernandez R.et.al.   11346655
[7] “Multifunctionality of plant ABC transporters -- more than just detoxifiers.”  Martinoia E.et.al.   11855639
[8] “Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana.”  Kolukisaoglu U.H.et.al.   12430019
[9] “Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters.”  Geisler M.et.al.   15133126
[10] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGFEFIEWYC KPVPNGVWTK QVANAFGAYT PCATDSFVLG ISQLVLLVLC LYRIWLALKD 
61:	HKVERFCLRS RLYNYFLALL AAYATAEPLF RLIMGISVLD FDGPGLPPFE AFGLGVKAFA 
121:	WGAVMVMILM ETKIYIRELR WYVRFAVIYA LVGDMVLLNL VLSVKEYYSS YVLYLYTSEV 
181:	GAQVLFGILL FMHLPNLDTY PGYMPVRSET VDDYEYEEIS DGQQICPEKH ANIFDKIFFS 
241:	WMNPLMTLGS KRPLTEKDVW YLDTWDQTET LFTSFQHSWD KELQKPQPWL LRALNNSLGG 
301:	RFWWGGFWKI GNDCSQFVGP LLLNQLLKSM QEDAPAWMGY IYAFSIFVGV VFGVLCEAQY 
361:	FQNVMRVGYR LRSALIAAVF RKSLRLTNEG RRKFQTGKIT NLMTTDAESL QQICQSLHTM 
421:	WSAPFRIIIA LILLYQQLGV ASLIGALLLV LMFPLQTVII SKMQKLTKEG LQRTDKRIGL 
481:	MNEVLAAMDT VKCYAWENSF QSKVQTVRDD ELSWFRKSQL LGALNMFILN SIPVLVTIVS 
541:	FGVFTLLGGD LTPARAFTSL SLFAVLRFPL FMLPNIITQV VNANVSLKRL EEVLATEERI 
601:	LLPNPPIEPG EPAISIRNGY FSWDSKGDRP TLSNINLDVP LGSLVAVVGS TGEGKTSLIS 
661:	AILGELPATS DAIVTLRGSV AYVPQVSWIF NATVRDNILF GSPFDREKYE RAIDVTSLKH 
721:	DLELLPGGDL TEIGERGVNI SGGQKQRVSM ARAVYSNSDV YIFDDPLSAL DAHVGQQVFE 
781:	KCIKRELGQK TRVLVTNQLH FLSQVDRIVL VHEGTVKEEG TYEELSSNGP LFQRLMENAG 
841:	KVEEYSEENG EAEADQTAEQ PVANGNTNGL QMDGSDDKKS KEGNKKGGKS VLIKQEERET 
901:	GVVSWRVLKR YQDALGGAWV VMMLLLCYVL TEVFRVTSST WLSEWTDAGT PKSHGPLFYN 
961:	LIYALLSFGQ VLVTLTNSYW LIMSSLYAAK KLHDNMLHSI LRAPMSFFHT NPLGRIINRF 
1021:	AKDLGDIDRT VAVFVNMFMG QVSQLLSTVV LIGIVSTLSL WAIMPLLVLF YGAYLYYQNT 
1081:	AREVKRMDSI SRSPVYAQFG EALNGLSTIR AYKAYDRMAD INGRSMDNNI RFTLVNMGAN 
1141:	RWLGIRLETL GGLMIWLTAS FAVMQNGRAE NQQAFASTMG LLLSYALNIT SLLTGVLRLA 
1201:	SLAENSLNAV ERVGNYIEIP PEAPPVIENN RPPPGWPSSG SIKFEDVVLR YRPQLPPVLH 
1261:	GVSFFIHPTD KVGIVGRTGA GKSSLLNALF RIVEVEKGRI LIDDCDVGKF GLMDLRKVLG 
1321:	IIPQSPVLFS GTVRFNLDPF GEHNDADLWE SLERAHLKDT IRRNPLGLDA EVSEAGENFS 
1381:	VGQRQLLSLS RALLRRSKIL VLDEATAAVD VRTDALIQKT IREEFKSCTM LIIAHRLNTI 
1441:	IDCDKILVLD SGRVQEFSSP ENLLSNEGSS FSKMVQSTGA ANAEYLRSLV LDNKRAKDDS 
1501:	HHLQGQRKWL ASSRWAAAAQ FALAASLTSS HNDLQSLEIE DDSSILKRTN DAVVTLRSVL 
1561:	EGKHDKEIAE SLEEHNISRE GWLSSLYRMV EGLAVMSRLA RNRMQQPDYN FEGNTFDWDN 
1621:	VEM