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3.A.1.208.6
Metal-thiol conjugate exporter, PgpA; glutathione and trypanothione conjugates are exported; confers arsenite and antimonite resistance (trypanothione is glutathione-spermidine).

Accession Number:P21441
Protein Name:PgpA
Length:1548
Molecular Weight:172236.00
Species:Leishmania tarentolae (Sauroleishmania tarentolae)   [5689]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Metal-thiol conjugates, Glutathione conjugates, Trypanothione conjugates, Ansenite, antimonite

Cross database links:

Pfam: PF00664    PF00005    PF01302   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0008559 F:xenobiotic-transporting ATPase activity
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (1)

[1] “The amplified H circle of methotrexate-resistant Leishmania tarentolae contains a novel P-glycoprotein gene.”  Ouellette M.et.al.   1969794

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVDNGHVTIA MADLGTVVEI AQVRCQQEAQ RKFAEQLDEL WGGEPAYTPT VEDQASWFQQ 
61:	LYYGWIGDYI YKAAAGNITE ADLPPPTRST RTYHIGRKLS RQAHADIDAS RRWQGYIGCE 
121:	VVYKSEAEAK GVLRWVGHLQ QSDYPRSLVA GVEWRMPPRH RRLAVLGSAA ALHNGVVHGE 
181:	RLFWPHEDNY LCSCEPVEQL YVKSKYNLIP PRPPPSPDLL RTLFKVHWYH VWAQILPKLL 
241:	SDVTALMLPV LLEYFVKYLN ADNATWGWGL GLALTIFLTN VIQSCSAHKY DHISIRTAAL 
301:	FETSSMALLF EKCFTVSRRS LQRPDMSVGR IMNMVGNDVD NIGSLNWYVM YFWSAPLQLV 
361:	LCLLLLIRLV GWLRVPGMAV LFVTLPLQAV ISKHVQDVSE RMASVVDLRI KRTNELLSGV 
421:	RIVKFMGWEP VFLARIQDAR SRELRCLRDV HVANVFFMFV NDATPTLVIA VVFILYHVSG 
481:	KVLKPEVVFP TIALLNTMRV SFFMIPIIIS SILQCFVSAK RVTAFIECPD THSQVQDIAS 
541:	IDVPDAAAIF KGASIHTYLP VKLPRCKSRL TAMQRSTLWF RRRGVPETEW YEVDSPDASA 
601:	SSLAVHSTTV HMGSTQTVIT DSDGAAGEDE KGEVEEGDRE YYQLVSKELL RNVSLTIPKG 
661:	KLTMVIGSTG SGKSTLLGAL MGEYSVESGE LWAERSIAYV PQQAWIMNAT LRGNILFFDE 
721:	ERAEDLQDVI RCCQLEADLA QFCGGLDTEI GEMGVNLSGG QKARVSLARA VYANRDVYLL 
781:	DDPLSALDAH VGQRIVQDVI LGRLRGKTRV LATHQIHLLP LADYIVVLQH GSIVFAGDFA 
841:	AFSATALEET LRGELKGSKD VESCSSDVDT ESATAETAPY VAKAKGLNAE QETSLAGGED 
901:	PLRSDVEAGR LMTTEEKATG KVPWSTYVAY LKSCGGLEAW GCLLATFALT ECVTAASSVW 
961:	LSIWSTGSLM WSADTYLYVY LFIVFLEIFG SPLRFFLCYY LIRIGSRNMH RDLLESIGVA 
1021:	RMSFFDTTPV GRVLNRFTKD MSILDNTLND GYLYLLEYFF SMCSTVIIMV VVQPFVLVAI 
1081:	VPCVYSYYKL MQVYNASNRE TRRIKSIAHS PVFTLLEESL QGQRTIATYG KLHLVLQEAL 
1141:	GRLDVVYSAL YMQNVSNRWL GVRLEFLSCV VTFMVAFIGV IGKMEGASSQ NIGLISLSLT 
1201:	MSMTLTETLN WLVRQVAMVE ANMNSVERVL HYTQEVEHEH VPEMGELVAQ LVRSESGRGA 
1261:	NVTETVVIES AGAASSALHP VQAGSLVLEG VQMRYREGLP LVLRGVSFQI APREKVGIVG 
1321:	RTGSGKSTLL LTFMRMVEVC GGVIHVNGRE MSAYGLRDVR RHFSMIPQDP VLFDGTVRQN 
1381:	VDPFLEASSA EVWAALELVG LRERVASESE GIDSRVLEGG SNYSVGQRQL MCMARALLKR 
1441:	GSGFILMDEA TANIDPALDR QIQATVMSAF SAYTVITIAH RLHTVAQYDK IIVMDHGVVA 
1501:	EMGSPRELVM NHQSMFHSMV ESLGSRGSKD FYELLMGRRI VQPAVLSD