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3.A.1.212.2
ABC mitochondrial peptide/MDR half transporter, MdlB. High copy number suppressor of ATM1 [iron-sulfur cluster transporter (3.A.1.210.1)]

Accession Number:P33311
Protein Name:MdlB
Length:773
Molecular Weight:85137.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate peptides, drugs

Cross database links:

Genevestigator: P33311
eggNOG: fuNOG07753
HEGENOM: HBG758042
DIP: DIP-4226N
RefSeq: NP_015053.2   
Entrez Gene ID: 855858   
Pfam: PF00664    PF00005   
KEGG: sce:YPL270W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (8)

[1] “Mapping and sequencing of two yeast genes belonging to the ATP-binding cassette superfamily.”  Dean M.C.et.al.   7912468
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.”  Bussey H.et.al.   9169875
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[4] “Role of the ABC transporter Mdl1 in peptide export from mitochondria.”  Young L.et.al.   11251115
[5] “Sequencing and comparison of yeast species to identify genes and regulatory elements.”  Kellis M.et.al.   12748633
[6] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[7] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[8] “The proteome of Saccharomyces cerevisiae mitochondria.”  Sickmann A.et.al.   14576278

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MLNGRLPLLR LGICRNMLSR PRLAKLPSIR FRSLVTPSSS QLIPLSRLCL RSPAVGKSLI 
61:	LQSFRCNSSK TVPETSLPSA SPISKGSARS AHAKEQSKTD DYKDIIRLFM LAKRDWKLLL 
121:	TAILLLTISC SIGMSIPKVI GIVLDTLKTS SGSDFFDLKI PIFSLPLYEF LSFFTVALLI 
181:	GCAANFGRFI LLRILSERVV ARLRANVIKK TLHQDAEFFD NHKVGDLISR LGSDAYVVSR 
241:	SMTQKVSDGV KALICGVVGV GMMCSLSPQL SILLLFFTPP VLFSASVFGK QIRNTSKDLQ 
301:	EATGQLTRVA EEQLSGIKTV QSFVAEGNEL SRYNVAIRDI FQVGKTAAFT NAKFFTTTSL 
361:	LGDLSFLTVL AYGSYLVLQS QLSIGDLTAF MLYTEYTGNA VFGLSTFYSE IMQGAGAASR 
421:	LFELTDRKPS ISPTVGHKYK PDRGVIEFKD VSFSYPTRPS VQIFKNLNFK IAPGSSVCIV 
481:	GPSGRGKSTI ALLLLRYYNP TTGTITIDNQ DISKLNCKSL RRHIGIVQQE PVLMSGTIRD 
541:	NITYGLTYTP TKEEIRSVAK QCFCHNFITK FPNTYDTVIG PHGTLLSGGQ KQRIAIARAL 
601:	IKKPTILILD EATSALDVES EGAINYTFGQ LMKSKSMTIV SIAHRLSTIR RSENVIVLGH 
661:	DGSVVEMGKF KELYANPTSA LSQLLNEKAA PGPSDQQLQI EKVIEKEDLN ESKEHDDQKK 
721:	DDNDDNDNNH DNDSNNQSPE TKDNNSDDIE KSVEHLLKDA AKEANPIKIT PQP