TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*3.A.29.1.1









The mitochondrial i-AAA protease complex involved in inner membrane insertion and turnover.  It consists of Yta10, Yta11 and Yta12 (Lee et al. 2017).

Eukaryota
Fungi
Protease complex of Saccharomyces cerevisiae
Yta10, Afg3 of 761 aas with 2 TMSs
Yta11, Yme1, Osd1, of 747 aas and 2 TMSs
Yta12, RCA1, of 825 aas
*3.A.29.1.2









Mitochondrial AAA protease complex of two enzymes, Yta10/12 (Afg3-like or Spg-7) and Yta11 (Ymel-1). It is a mitochondrial ATP-dependent metalloprotease complex mediating degradation of non-assembled mitochondrial inner membrane proteins and necessary for the assembly of the mitochondrial respiratory chain and ATPase complexes. It functions both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides (Nargund et al. 2012, Pellegrino et al. 2014, Nargund et al. 2015).

Eukaryota
Metazoa
Protease complex of Caenorhabditis elegans
Spg-7 (Ata10/12), 782 aas and 2 TMSs
Yme1 (Ata11; Ymel-1), 723 aas and 1 TMS