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3.A.3.1.10
Putative archaeal Na+, K+ ATPase, Mac8 (encoded with methylcobalamin: coenzyme M methyltransferase; methanol-specific, a metal chaparone protein and an electron transfer protein) (Chan et al., 2010).

Accession Number:Q8THY0
Protein Name:Sodium/potassium-transporting ATPase, alpha subunit
Length:929
Molecular Weight:101898.00
Species:Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [188937]
Number of TMSs:10
Substrate Na+, K+

Cross database links:

HEGENOM: HBG456486
Entrez Gene ID: 1476272   
Pfam: PF00689    PF00690    PF00122    PF00702   
KEGG: mac:MA4378   

Gene Ontology

GO:0016020 C:membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0006812 P:cation transport

References (1)

[1] “The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.”  Galagan J.E.et.al.   11932238

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKELDENKN QICSPQGDEH LISYSEFLQR LGVNENGLSE QEAARRLKEC GPNVLEESGK 
61:	ESIFKRYIRQ FRNFFSILLT VGALLSFLGE YLDPGEGNLY IGIALIGVVF LNGTFTFVQE 
121:	YQAAKTMESF RQLLPPHAKV FRDGKVKDIL ASELVVGDVI LLEEGDKVPA DGRLIETNAL 
181:	KVDNSALTGE SEPQLRSIEC THENMLECRN MVFSGTLVQS GNGKAIVFGT GQDTQIGSLA 
241:	TLTEQTTSVD TPIRKELNHF IKIISAIAIF LGITFFLLAF FLQDIFLASL IFAIGIIVAN 
301:	VPEGLLPTVT LALSLASRRM ATRNALIKQL ESVETLGSTT VICTDKTGTL TQNRMAVNSL 
361:	ILGFESLERE KPSSPQEGGE SGSKELTGNP GWAPEKIPPV FIRVAGLCNN AKLYEAPPGY 
421:	TGDPTEGALL VFANGFVDVK ALQREYPRQE EFPFDSLTRR MEVVCRTPED KLEVYLKGAP 
481:	EVVVQMCGSI LESGEIRKLD EAGQKELLGR HLKLAEKGER IIALAFRQAD AQKEYTGDFI 
541:	FLGFIGIIDP PRPEAREAIA KCHAAGIKVV MITGDHPVTA ESIARDVGLA AFGTPEIITG 
601:	DELKSLSRTE LASRLKNPSI VFARTSPVQK LKIVQLFQAE GEIVTMTGDG VNDAPAIKNA 
661:	DMGVAMGSGT DVAREAADMV LLDDNFATIV NAVEEGRTVF DNIKKFIAYI LTSNIPEILP 
721:	FIAFVLLSIP LPMPVQLILA IDLGTDILPA IALGVEKGEG DIMKRPPRPR DEKLLTSQVL 
781:	LTSYGVKGPI EAAAGFFCYF AVLFGGGWTY GEQLANNNPI YMQAITAFFS AIIICQIANV 
841:	FVSRTRFQSV FSMGFFSNRM VLLGIASELL ILALIIWNPV ANLIFNTAPI DFKYMLLAVP 
901:	FAVFLLGVDE LRKYLLRKNV SWVARFFKW