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3.A.3.2.12
Endomembrane plasma membrane-type Ca2+ ATPase, ACA2 (Arabidopsis Ca2+ ATPase isoform 2) (lacks a C-terminal calmodulin domain, but activity is stimulated 5x by calmodulin which binds to an N-terminal inhibitory domain (Harper et al., 1998; Kamrul Huda et al. 2013).

Accession Number:O81108
Protein Name:Calcium-transporting ATPase 2, plasma membrane-type aka ACA2
Length:1014
Molecular Weight:110439.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: O81108
eggNOG: KOG0204
HEGENOM: HBG456486
RefSeq: NP_195479.1   
Entrez Gene ID: 829918   
Pfam: PF00689    PF00690    PF00122    PF00702   
BioCyc: MetaCyc:MONOMER-14659   
KEGG: ath:AT4G37640   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0005388 F:calcium-transporting ATPase activity
GO:0005516 F:calmodulin binding
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0006816 P:calcium ion transport

References (4)

[1] “A novel calmodulin-regulated Ca2+-ATPase (ACA2) from Arabidopsis with an N-terminal autoinhibitory domain.”  Harper J.F.et.al.   9422775
[2] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “A calcium-dependent protein kinase can inhibit a calmodulin-stimulated Ca2+ pump (ACA2) located in the endoplasmic reticulum of Arabidopsis.”  Hwang I.et.al.   10823962
Structure:
2M7E     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MESYLNENFD VKAKHSSEEV LEKWRNLCGV VKNPKRRFRF TANLSKRYEA AAMRRTNQEK 
61:	LRIAVLVSKA AFQFISGVSP SDYTVPEDVK AAGFEICADE LGSIVESHDV KKLKFHGGVD 
121:	GLAGKLKASP TDGLSTEAAQ LSQRQELFGI NKFAESEMRG FWVFVWEALQ DMTLMILGVC 
181:	AFVSLIVGIA TEGWPKGSHD GLGIAASILL VVFVTATSDY RQSLQFRDLD KEKKKITVQV 
241:	TRNGFRQKLS IYDLLPGDIV HLAIGDQVPA DGLFLSGFSV VIDESSLTGE SEPVMVNAQN 
301:	PFLMSGTKVQ DGSCKMMITT VGMRTQWGKL MATLTEGGDD ETPLQVKLNG VATIIGKIGL 
361:	FFAVVTFAVL VQGMFMRKLS TGTHWVWSGD EALELLEYFA IAVTIVVVAV PEGLPLAVTL 
421:	SLAFAMKKMM NDKALVRHLA ACETMGSATT ICSDKTGTLT TNHMTVVKSC ICMNVQDVAN 
481:	KGSSLQSEIP ESAVKLLIQS IFNNTGGEVV VNKHGKTELL GTPTETAILE LGLSLGGKFQ 
541:	EERKSYKVIK VEPFNSTKKR MGVVIELPEG GRMRAHTKGA SEIVLAACDK VVNSSGEVVP 
601:	LDEESIKYLN VTINEFANEA LRTLCLAYMD IEGGFSPDDA IPASGFTCVG IVGIKDPVRP 
661:	GVKESVELCR RAGITVRMVT GDNINTAKAI ARECGILTDD GIAIEGPVFR EKNQEELLEL 
721:	IPKIQVMARS SPMDKHTLVK QLRTTFDEVV AVTGDGTNDA PALHEADIGL AMGIAGTEVA 
781:	KESADVIILD DNFSTIVTVA KWGRSVYINI QKFVQFQLTV NVVALVVNFS SACLTGSAPL 
841:	TAVQLLWVNM IMDTLGALAL ATEPPNDELM KRLPVGRRGN FITNAMWRNI LGQAVYQFIV 
901:	IWILQAKGKA MFGLDGPDST LMLNTLIFNC FVFCQVFNEI SSREMEEIDV FKGILDNYVF 
961:	VVVIGATVFF QIIIIEFLGT FASTTPLTIT QWIFSIFIGF LGMPIAAGLK TIPV