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3.A.3.2.13
Endoplasmic reticular (ER)-type Ca2+/Mn2+ ATPase, ECA1; 80% identical to and orthologous to the Medicago truncatula MCA8 protein of 1081 aas (F9W2W4). 42 P-type II Ca2+ ATPase genes have been found in Triticum aestivum. which may play roles in plant growth, development and signalling during abiotic and biotic stresses (Taneja and Upadhyay 2018).

Accession Number:P92939
Protein Name:Calcium-transporting ATPase 1, endoplasmic reticulum-type aka ECA1
Length:1061
Molecular Weight:116366.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Mn2+, Ca2+

Cross database links:

Genevestigator: P92939
HEGENOM: HBG456486
RefSeq: NP_172259.1   
Entrez Gene ID: 837296   
Pfam: PF00689    PF00690    PF00122    PF00702   
BioCyc: MetaCyc:MONOMER-14600   
KEGG: ath:AT1G07810   

Gene Ontology

GO:0030176 C:integral to endoplasmic reticulum membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0005388 F:calcium-transporting ATPase activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0006816 P:calcium ion transport
GO:0030026 P:cellular manganese ion homeostasis
GO:0006828 P:manganese ion transport
GO:0046686 P:response to cadmium ion
GO:0010042 P:response to manganese ion

References (3)

[1] “ECA1 complements yeast mutants defective in Ca2+ pumps and encodes an endoplasmic reticulum-type Ca2+-ATPase in Arabidopsis thaliana.”  Liang F.et.al.   9238019
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “An endoplasmic reticulum-bound Ca(2+)/Mn(2+) pump, ECA1, supports plant growth and confers tolerance to Mn(2+) stress.”  Wu Z.et.al.   12226493

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGKGSEDLVK KESLNSTPVN SDTFPAWAKD VAECEEHFVV SREKGLSSDE VLKRHQIYGL 
61:	NELEKPEGTS IFKLILEQFN DTLVRILLAA AVISFVLAFF DGDEGGEMGI TAFVEPLVIF 
121:	LILIVNAIVG IWQETNAEKA LEALKEIQSQ QATVMRDGTK VSSLPAKELV PGDIVELRVG 
181:	DKVPADMRVV ALISSTLRVE QGSLTGESEA VSKTTKHVDE NADIQGKKCM VFAGTTVVNG 
241:	NCICLVTDTG MNTEIGRVHS QIQEAAQHEE DTPLKKKLNE FGEVLTMIIG LICALVWLIN 
301:	VKYFLSWEYV DGWPRNFKFS FEKCTYYFEI AVALAVAAIP EGLPAVITTC LALGTRKMAQ 
361:	KNALVRKLPS VETLGCTTVI CSDKTGTLTT NQMAVSKLVA MGSRIGTLRS FNVEGTSFDP 
421:	RDGKIEDWPM GRMDANLQMI AKIAAICNDA NVEQSDQQFV SRGMPTEAAL KVLVEKMGFP 
481:	EGLNEASSDG DVLRCCRLWS ELEQRIATLE FDRDRKSMGV MVDSSSGNKL LLVKGAVENV 
541:	LERSTHIQLL DGSKRELDQY SRDLILQSLR DMSLSALRCL GFAYSDVPSD FATYDGSEDH 
601:	PAHQQLLNPS NYSSIESNLI FVGFVGLRDP PRKEVRQAIA DCRTAGIRVM VITGDNKSTA 
661:	EAICREIGVF EADEDISSRS LTGIEFMDVQ DQKNHLRQTG GLLFSRAEPK HKQEIVRLLK 
721:	EDGEVVAMTG DGVNDAPALK LADIGVAMGI SGTEVAKEAS DMVLADDNFS TIVAAVGEGR 
781:	SIYNNMKAFI RYMISSNIGE VASIFLTAAL GIPEGMIPVQ LLWVNLVTDG PPATALGFNP 
841:	PDKDIMKKPP RRSDDSLITA WILFRYMVIG LYVGVATVGV FIIWYTHSSF MGIDLSQDGH 
901:	SLVSYSQLAH WGQCSSWEGF KVSPFTAGSQ TFSFDSNPCD YFQQGKIKAS TLSLSVLVAI 
961:	EMFNSLNALS EDGSLVTMPP WVNPWLLLAM AVSFGLHFVI LYVPFLAQVF GIVPLSLNEW 
1021:	LLVLAVSLPV ILIDEVLKFV GRCTSGYRYS PRTLSTKQKE E