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3.A.3.2.15
Plasma membrane Ca2+ ATPase, Mca1 (Kraev et al., 1999)

Accession Number:O45215
Protein Name:Cation-transporting ATPase aka mca-1
Length:1228
Molecular Weight:134553.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: meNOG05651
RefSeq: NP_001023426.1   
Entrez Gene ID: 177795   
Pfam: PF00689    PF00690    PF00122    PF00702   
KEGG: cel:W09C2.3   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0005388 F:calcium-transporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0006816 P:calcium ion transport

References (2)

[1] “Identification and functional expression of the plasma membrane calcium ATPase gene family from Caenorhabditis elegans.”  Kraev A.et.al.   9933625
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MRLRRGHTYD EDAKEFGCSL GDLRGLMEAR GAEAIVRLST EHEGVEGLCK KLKTDSLVGL 
61:	NGEQADLDRR RHVYGANTIP PAKSKGFVRL VLDACKDPTL VILVLSGFIN LALSFYEPTS 
121:	AAEDATQHLV NATTAAILAN GTFMSTTEAP SEGHGTAWIE GVAILLCVIV VVLVTAVNDY 
181:	SKERQFRSLQ EKIETGQKFS VIRNGEAIDV PVSDLVVGDI ARVKYGDLLP ADGFLIQSND 
241:	LKIDESSLTG ESDHIKKSIE SDPVLLSGTY AMEGSGKMLI TAVGVNSQTG IIMTLLGAGK 
301:	AGIGDDDSTS TSSSSSSSSS SSGSSSNGSS DSSKSGDDDL TAKSVLQAKL SKLALQIIYC 
361:	GTTIAIIALI VLVTRFCLDH YVFEKNEFSL VDIQMFVKFF IIAVTILVIS IPEGLPLAIA 
421:	LALTYSVRKM MHDNNLVRHL DACETMGNAT SICSDKTGTL TTNRMTVVQS YINGNHYTSQ 
481:	EAQPHGANLP GSTGPILMEA ISVNCAYNSM IVEPTKAGEQ IQQLGNKTEC GLLGFVNRLG 
541:	GDYAAIRKKF PEHDLTKVYT FNSSRKCMMT VVPYAENGQN IGYRVYCKGA SEIVLGRCTY 
601:	LIGSDGKPHQ LTGDRLKEIT STIIHEMANS GLRTICVAYK TIIKKGTRDV EKTEIEFAED 
661:	SDIDWDDEDA MYQNFTGIAI CGIQDPVRPE VPVAISKCKK AGITVRMVTG DNIMTARAIA 
721:	MSCKILEPGE DFLALEGKEF NERIRDENGK VSQAKLDEIW PRLRVLARAQ PADKYTLVKG 
781:	IIDSKATPQR EIVAVTGDGT NDGPALKKAD VGFAMGIAGT DVAKEASDII LTDDNFTSIV 
841:	KAVMWGRNVY DSISKFLQFQ LTVNVVAVIT AFVGAVTVSD SPLKAVHMLW INLIMDTLAS 
901:	LALATEQPTD ELLERKPYGR KKSLISRTMV KNILCHALYQ LIIIFVIFFY GDTIFGIKTG 
961:	LYAPLFAPPS QHFTLVFNAF VMMTVFNEIN ARKVHGERNV FKGLASNRVF CVIWVTTFIA 
1021:	QIIIVQFGGA WFSTAPLTLQ QWIVCLVLGF STLIWGQIVA TIPSKKLPKA WKVGKGEVQP 
1081:	ANLHINGDYN VRARSRAVTL RRSGKSLWVR GMFIIGNHLR VLRAFGMEKS EKAAFGRTAP 
1141:	AMTAEAAERW RASYRKYRHQ KHQEKKATAE TAESVKSADW AKEQKEKKKT FKQIKQVARG 
1201:	KSLDKDSKKH HKKRKDQTNV DMEDIELN