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3.A.3.2.16
Golgi Ca2+, Mn2+ ATPase, PMR1 (Van Baelen et al., 2001). (The human orthologue ATP2Cl, TC#3.A.3.2.5, causes Hailey-Hailey disease.)

Accession Number:Q9XTG4
Protein Name:Cation-transporting ATPase aka pmr1
Length:901
Molecular Weight:98506.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Mn2+, Ca2+

Cross database links:

RefSeq: NP_001021860.1   
Entrez Gene ID: 173176   
Pfam: PF00689    PF00690    PF00122    PF00702   
KEGG: cel:ZK256.1   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0005388 F:calcium-transporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0006816 P:calcium ion transport

References (2)

[1] “The Golgi PMR1 P-type ATPase of Caenorhabditis elegans. Identification of the gene and demonstration of calcium and manganese transport.”  Van Baelen K.et.al.   11134055
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MIETLTSEQA ASHEVVPCTH QLRTNLEEGL TTAEATRRRQ YHGYNEFDVG EEEPIYKKYL 
61:	EQFQNPLILL LLASAFVSIV MKQYDDAISI TVAVVIVVTV GFVQEYRSEK TLEQLTKLVP 
121:	PTCHVLRDGK EAMMLARELV PGDIVLLNTG DRIPSDLRIA ESFSLQIDES SLTGETEPKH 
181:	KETRSVPAAS ATGSDVEHLT CIAFMGTLVC AGRGRGIVIS TAANSQFGEV VKMMMGEESP 
241:	KTPLQKSMDD LGKQLSIYSF GVIAVIFLIG MFQGRNVVDM FTIGVSLAVA AIPEGLPIVV 
301:	AVTLAIGVMR MAKRRAVVKK MPAVETLGCV TVICSDKTGT LTKNEMTAQA IATPEGKLAE 
361:	ITGIGYSAEG GVVQYQGEQV HQWTHPEFAR IIEAGLVCNN ATIEADKLIG QPTEGAIVVL 
421:	AKKAQLEGVR SEYKRLREMP FSSDTKWMGV QCADAHGQNV YFIKGALDRV LDQCGTYYSS 
481:	DNQRKQCDQY SRQHILEIGK ELGQKGLRVL GLARGESMQS LMFLGMIGMM DPPRPGAADA 
541:	ISIVKASGVD VKLITGDAME TAQSIGQSLG ILSSSDSCLS GQQVDQMSDH DLELVIRQVT 
601:	VFYRASPRHK LKIVKALQAL GEVVAMTGDG VNDAVALKKA DIGVAMGVCG TDVCKEAADM 
661:	ILCDDDFSTM TAAIEEGKAI YHNITNFVRF QLSTSVAALS LIAASTMFKF DNPLNAMQIL 
721:	WINIIMDGPP AQSLGVEPVD DDIIRQRPRN TKQPMLTGKL IADILASAAI IVVGTLSVFY 
781:	KEMSADNKVT PRDTTMTFTC FVLFDMWNAL SCRSSRKMIW QIGLRRNRMF SLAVSASLIC 
841:	QLLVIYWAPL QHIFQTEALS LFDLIFLTTI TSSVFIFNET RKYFSLRSKS LNHDPLSVSG 
901:	I