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3.A.3.2.17
Intracellular (contractile vacuole) Ca2+ ATPase, PatA (lacks the C-terminal calmodulin domain of most plasma membrane Ca2+ ATPases) (Moniakis et al., 1995)

Accession Number:P54678
Protein Name:Probable calcium-transporting ATPase PAT1 aka PATA
Length:1115
Molecular Weight:120677.00
Species:Dictyostelium discoideum (Slime mold) [44689]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Contractile vacuole membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: KOG0204
HEGENOM: HBG456486
RefSeq: XP_642164.2   
Entrez Gene ID: 8621371   
Pfam: PF00689    PF00690    PF00122    PF00702   
KEGG: ddi:DDB_0214945   

Gene Ontology

GO:0031164 C:contractile vacuolar membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0005509 F:calcium ion binding
GO:0005388 F:calcium-transporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0006816 P:calcium ion transport

References (3)

[1] “Molecular cloning of an intracellular P-type ATPase from Dictyostelium that is up-regulated in calcium-adapted cells.”  Moniakis J.et.al.   7499325
[2] “The genome of the social amoeba Dictyostelium discoideum.”  Eichinger L.et.al.   15875012
[3] “Involvement of the Ca2+-ATPase PAT1 and the contractile vacuole in calcium regulation in Dictyostelium discoideum.”  Moniakis J.et.al.   9885293

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTGSHEMESI MLDSMEEEFP VSVETLGKLV DVPKGFDTYA ELGGLSGLST KLKSNIKTGL 
61:	PLEKSSTEEN RVLKYSKNIL PDPPHQPLWS IVLDALSDHI LILLIVAAVV SIVLGSIDYT 
121:	SDHPETGWID GVAILVAVIL VVGITSLNDF KNQARFRELN DKSNDKEVKG IRGGEQCQIS 
181:	IFDVKVGDII SLDTGDIICA DGVFIEGHAL KCDESSITGE SDPIKKGQPQ DNMDPFLISG 
241:	SMVIEGFGTM LVTAVGVNSF NGKTMMGLRV ASEDTPLQMK LSVLASRIGY FGMGAAILML 
301:	LIAIPKYFIQ RKVHDIEITR EDAQPIVQLV ISAITIVVVA VPEGLPLAVT MALAYGMMKM 
361:	FKENNLVRNL ASCETMGSAT TICSDKTGTL TQNVMSVVTG TICGVFPTLD GIAQKIPKHV 
421:	QSILTDGMAI NSNAYEGVSS KGKLEFIGSK TECALLNFGK LFGCDYNEVR KRLEVVELYP 
481:	FSSARKRMSV LVKHDQNLRL FTKGASEIIL GQCGSYLDEA GNIRPISEAK AYFEEQINNF 
541:	ASDALRTIGL AYRDFQYGEC DFKEPPENNL VFIGIVGIKD PLRPEVPEAV EICKRAGIVV 
601:	RMVTGDNLVT AQNIARNCGI LTEGGLCMEG PKFRELSQSE MDAILPKLQV LARSSPTDKQ 
661:	LLVGRLKDLG EVVAVTGDGT NDGPALKLAN VGFSMGISGT EVAIAASDVV LLDDNFASIV 
721:	RAVLWGRNIY DAICKFLQFQ LTVNVVAVTV AFIGTLTSDV VEDKDNSSSS GSADKVTEEE 
781:	PRQGSPLTAV QLLWVNLIMD TLAALALATE PPTPELLERP PNGKNAPLIT RSMWKNIIGQ 
841:	AALQLAILFT ILYQGHNIFQ HFVPQAHGPI IKNGLHHYTL VFNCFVFLQL FNEINARVLG 
901:	SRTNPFKNFF NNPIFIAVMI FTLGVQIIFV TFGGSATSTD SLYIVEWICC VVVGAISLPV 
961:	GLLLRKIPIR EPVVKNEIPV HSEAVYTSPS PNPSSSNLLG SGGAKPISKD YPTSGESTPP 
1021:	INDEGSPLVT RKTSVGASAN DNINTPIPSS SSNLVNLNKP TQVGRGWQIV RQTHKKLVVI 
1081:	NALKEFSQNK EPGLVDVVRG TNRGSLHLPV NQINN