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3.A.3.2.18
The acidocalcisome (vacuole) Ca2+/H+ ATPase TgA1 (involved in Ca2+ homeostasis, vacuolar polyphosphate storage and virulence) (Luo et al., 2005).

Accession Number:Q9N694
Protein Name:Cation-transporting ATPase aka TgA1
Length:1405
Molecular Weight:152837.00
Species:Toxoplasma gondii [5811]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate H+, Ca2+

Cross database links:

Pfam: PF00689    PF00690    PF00122    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0005388 F:calcium-transporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0006816 P:calcium ion transport

References (1)

[1] “A plasma membrane-type Ca(2+)-ATPase co-localizes with a vacuolar H(+)-pyrophosphatase to acidocalcisomes of Toxoplasma gondii.”  Luo S.et.al.   11226155

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGGVRAIASA LGSDLADGLP ILKRHDSSLR ASSFDGAAAI RESSHGFETV VVRTLGSLQT 
61:	GDAATGVTLG RSETREAPQR PRCLQTRPAG SDADPLTGLA SQESWITRLL RRSIGSEQGG 
121:	DLVQTQQRRF GVNRIPHRPL TSFWTLLIEA ASDATLRVLM LCGLLSVVLA LLFSKEPEVE 
181:	ILEGIAIWVA VLVVVVVTAG NDWMKEQQFA KLSVVKDDKK CTVVRSGHKE QISVFQLVVG 
241:	DILHLEAGDE VPADALVVQG RDLTVDESSL TGESDMIRKA PFQQCLNEAL SRETAFSSAL 
301:	DSAENLPAPG SSVDHRRRSR GSFGAPSSGA PLQAQTCTTS SACADTLKSE GGVCTQLELA 
361:	RHHEVASPVL LSGTTVSTGS GTALVVAVGR YSQVGQMFQK LAYDAEPTPL QRKLNALAED 
421:	IGTFGLISAV VAFFVLLLEF WVMYFLQDPS KRESAVDVVH DHVEFFVTAI TMLVVAVPEG 
481:	LPLAVTISLA YSIGQMLRDQ NYVRRLAACE IMGGANEICS DKTGTLTKNQ MTVTQFWDGE 
541:	KTFCIPSSRG EQTPGADPLS TGAEGEDVGD DMSLHAQDAS RRGYIPLSAH STAASSASPH 
601:	FAKSSCGGAA VSEGLAELQE KNFKWEVLMQ AIALNSTAFL ETEEVVVAQG TGEETRFTQV 
661:	KHVGSPTECA LLAFQDERCG GDYASTRRLY LGEDEVELIA REDFSSDRKM MTSVVRILKN 
721:	SGDSTGATSP ASPGLLRVFV KGAGERVLAQ CSSVLVADQV IPLTPERKAE VEKTVVDAMA 
781:	AEALRTICLA YRDIDPEREP DWRERCAAPH QMFMKGETQL TCLGIAGIED PVRDEVPGAV 
841:	AQCQRAGIKV RMVTGDNIIT AKAIAKRCEI FHEESGGLAM LGPDFTRAIG GVVCQTCQTE 
901:	VCACATDAKT AEEQNKPLRV DVVRDLDAFD KIWTRLEVLA RSQPSDKYAL VTALKQKGRV 
961:	VAVTGDGTND APALKKADVG FAMGLSGKEV AKQAADIVML DDNFTCIVKA VKWGRNVYDN 
1021:	IRRFLQFQLT VNVVAVALTV VCTAVQREAP LSAVQMLWVN LIMDSFASLA LATESPTDDL 
1081:	LNRKPQGRDS YLISRSMLTS IVAASIYQLT VMIGLIFFGE RFLPETKWTF LSDEDRRNLG 
1141:	FCEFSDCDFG MYTGTRMLSG RRYKLFSTED DYKLEWLREV GPSRHGTFVF NTFVFMQIFN 
1201:	TINARDVDDT QIEKSTSLSA AILGMVRNPL GLGIWVLIVL GQVLMTECGG RLLGCHQEGL 
1261:	NREQWMLSLL LGLGGLLWGR LPRVFPSLYK LAPEFGSREE TLEETHSLAL ELRGRTPERM 
1321:	NERLGLASYT FAKKYAKKAR LMTLSRLRTR RLEGGRDGRG RGVSSFAGIR NRGASRGDAR 
1381:	VAPRQNKACS PPLSDAREEA CIEMQ