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3.A.3.2.28
The probable Mg2+/Ca2+ ATPase antiporter (catalyzes Mg2+ uptake and Ca2+ efflux in a single coupled step; Neef et al. 2011)

Accession Number:Q04JJ5
Protein Name:Cation-transporting ATPase, E1-E2 family protein
Length:898
Molecular Weight:97040.00
Species:Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) [373153]
Number of TMSs:10
Substrate Ca2+, Mn2+

Cross database links:

eggNOG: COG0474 COG0474
HEGENOM: HBG456486 HBG456486
Entrez Gene ID: 4442797   
Pfam: PF00689    PF00690    PF00122    PF00702   
KEGG: spd:SPD_1383    spd:SPD_1383   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0006812 P:cation transport

References (2)

[1] “Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6.”  Lanie J.A.et.al.   17041037
[2] “Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6.”  Lanie J.A.et.al.   17041037

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSKEQKRQAF YTQSPEEVLQ AVDATEQGLS SSEAEKRLAE FGHNELEEGE KRSILVKFIE 
61:	QFKDLMIIIL VAAAILSVVT SGGEDIADAI IILAVVIINA AFGVYQEGKA EEAIEALKSM 
121:	SSPVARVLRD GHMAEIDSKE LVPGDIVALE AGDVVPADLR LIEANSLKIE EAALTGESVP 
181:	VEKDLSVDLA TDAGIGDRVN MAFQNSNVTY GRGMGVVVNT GMYTEVGHIA GMLQDADETD 
241:	TPLKQNLNNL SKVLTYAILV IALVTFVVGV FIQGKNPLGE LLTSVALAVA AIPEGLPAIV 
301:	TIVLSLGTQV LAKRHSIVRK LPAVETLGST EIIASDKTGT LTMNKMTVEK VFYDAVLHDS 
361:	ADDIELGLEM PLLRSVVLAN DTKIDVEGNL IGDPTETAFI QYALDKGYDV KGFLEKYPRV 
421:	AELPFDSDRK LMSTVHPLPD SRFLVAVKGA PDQLLKRCLL RDKAGDIAPI DEKVTNLIHT 
481:	NNSEMAHQAL RVLAGAYKII DSIPENLTSE ELENDLIFTG LIGMIDPERP EAAEAVRVAK 
541:	EAGIRPIMIT GDHQDTAEAI AKRLGIIDAN DTEGHVLTGA ELNELSDEEF EKVVGQYSVY 
601:	ARVSPEHKVR IVKAWQKQGK VVAMTGDGVN DAPALKTADI GIGMGITGTE VSKGASDMIL 
661:	ADDNFATIIV AVEEGRKVFS NIQKTIQYLL SANTAEVLTI FLSTLFGWDV LQPVHLLWIN 
721:	LVTDTFPAIA LGVEPAEPGV MNHKPRGRKA SFFSGGVLSS IIYQGVLQAA LVMSVYGLAI 
781:	AYPVHVGDNH AIHADALTMA FATLGLIQLF HAYNVKSVYQ SILTVGPFKS KTFNWSILVS 
841:	FILLMATIVV EPLEGIFHVT KLDLSQWGIV MAGSFSMIII VEIVKFIQRK LGFDKNAI