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3.A.3.2.8
Ca2+-ATPase (efflux) with broad Ca2+ dependence (3.2-320 μm).  Probably inhibited by cipargamin and SJ1733 (Meier et al. 2018).

Accession Number:Q27724
Protein Name:PfATPase4
Length:1228
Molecular Weight:135990.00
Species:Plasmodium falciparum [5833]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Basal cell membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Pfam: PF00689    PF00690    PF00122    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0006754 P:ATP biosynthetic process
GO:0006812 P:cation transport

References (1)

[1] “Analysis of a cation-transporting ATPase of Plasmodium falciparum.”  Dyer M.et.al.   8813672

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSSQNNNKQG GQDINNKKDS DDIKPSVSKE DLINSLKNDE LNKNTTMDQN DMKKNENMNI 
61:	KKNEVLNNSN NVEDGDNENS KFMNKSKEGL NNINGEKNDD NNSIVKVEES PKSIGYNYYA 
121:	SESIENLCKE FGLESINTGL NSEQVKINRD KYGENFIEKD EVVPVWLIFL SQYCSPVVLL 
181:	LLVAAVASLA LNEVVEGVAI ISIVTLNACL ATYMEKSSGD AIGKLAEMAS PQCTVLRNGQ 
241:	KVVIPSREVV VGDVVLINTG DSISADLRLF DVIELKTNES LLTGESEDIK KTIVADNLST 
301:	PFATNLCFAT TSVTSGSGKG IVISTGLDTQ VGKIASQLKK SSKGSKLTPL QVALNKLGGL 
361:	IGLIAIIVLV VIISLAVIIK YRDPAHADKD PTFVIIIIGV GFAVSSIPEG LPMVVTITLS 
421:	AGAKDMVKKN ANVRKLPAVE TLGCCSVICS DKTGTLTEGK MTAINAVTIC KNSSLSDENN 
481:	KLTKTFDFYP TKGFEPCGGL FDSNELTSEK KKEIVIAKNQ NTSYDKVLYN YGNPSNKSVI 
541:	VDKTRSLMFA AYLNSYDTTL SRDPKTLKWG IHGNMSEGPI VVAAAKVGYS FINNPNHKSY 
601:	LDNFQRLDDL EVTFNSSRKM KITFYKLKTV NVFENVYLDK PRKEYTHIAL IKGAPDRLLD 
661:	RSTHLLEETS MKKVQVSWNS TITQEERNVL IKKNLELSQK ALRVLSICIK PLTDQNIEEL 
721:	KKLEDADADE RLKYVNYDEN GGFIPMGYVA SFDPPRPGVK EAIQTCREAQ VKVIMITGDQ 
781:	KPTAVAIGKL IGLIEEKSEQ VEDINSLAIE CSELHINKNP NEPILPNDQL DEFTDKILIY 
841:	SRAQQEDKIT IVQSLKRKGY LVAMTGDGVN DAPALKAADI GVAMGINGTE VAKGASEMIL 
901:	IDDNFCTVVS AIDVGRTIFS NIQKFVCFLL GTNIGEIIYL SVAIVAQMPF PLEALQILFL 
961:	NLMTDGCPAV ALSREPPNDD NMKTPPRPKK QPIMTKRWWF YGILPHTIFE ALCVLLSLAF 
1021:	SLYICTGFYN LNGIHNLCKT VNLVDVNDAN VYHEYKYFCS SYEYRISTDY VGWVTNVSFW 
1081:	DPQNNEAVNF WGAAKGKVEN INPLSDIVHP ELRLRMQDGC SGDLTLDENR WCRPKDNKTS 
1141:	DGYNDELEGI LKKGFEDVTA KGSKRGRTMA FISAVWCEML RAYTVRRREP FYKVFNRNMW 
1201:	MHLACSISAT LTFLSTCIPG ITSILNTT