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3.A.3.25.2
Functionally uncharacterized P-type ATPase family 25 (FUPA25.2) (3 proteins from α- and β-proteobacteria; 617-759 aas). These proteins show greatest similarity with established families 5&6. Family 25 members have 6 TMSs and lack TMSs A&B. Some fairly close homologues have 7 TMSs.

Accession Number:Q92Z60
Protein Name:Cation-transporting ATPase aka FUPA25.2
Length:799
Molecular Weight:85516.00
Species:Rhizobium meliloti (Sinorhizobium meliloti) [382]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

HEGENOM: HBG507745
RefSeq: NP_435878.2   
Entrez Gene ID: 1235668   
Pfam: PF00122    PF00702   
BioCyc: SMEL266834:SMA1163-MONOMER   
KEGG: sme:SMa1163   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0046872 F:metal ion binding
GO:0046873 F:metal ion transmembrane transporter activity
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (1)

[1] “Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid.”  Barnett M.J.et.al.   11481432

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRDIAQNQDN GSGIQYSSRD LLESTLTRSR DFAPIWQGGE LGKRLLLALI AVAMLAGIVT 
61:	WLAGRPDLSA ASWAAGTAVI LASLLTEIAI SLGRKEFGLD LIAALAMGGA LILGEYLTGT 
121:	IVALMYTGGE ALEDFAQRRA RRELTALLNR VPRTAVRYAD GQLQEVSIEE LNPGDRILIR 
181:	RGEVVPVDGS VMDGIAVLDE SALTGEAMPI RRRSGEPVTS GTTNAGDAFE MVASSAASDS 
241:	TYAAIVRLVE AAKAAKAPIV RLADRYALGF LAVTLLLAGG AWAISGEPVR ALAVLVIATP 
301:	CPLILAVPVA IIAGVSRCAG KGVLVKGGGA LEMLARIKTV ILDKTGTITD GRAHLIELKS 
361:	RTDLDPLEVL RLAASLDQGS HHVIARALVA AARERGLQLV APSGTRESAG SGVSGNIDGH 
421:	EIAVGGWDFI SERIDETAFS RDIRTWIRRD GVVSVLAAMD GVLAGAFLLA DEVRPEVGSV 
481:	LRQLREAGVR RIVLATGDRT ELAESLQSFL RLDNVAAELK PEDKTRIVEA ERAAGPVMMV 
541:	GDGVNDAPAL AAADVGVAMG ARGAAASSEA ADVVILVDRL DRLVSAIRIA HRSRGIALQS 
601:	VYMGMALSAA GMVAAAFGYL TPVQGALLQE AIDIVAILNA LRALGDPMRG WRKTTRLEHA 
661:	ELLKLEAEHR ALMDVVDEIR HTSARIQDLP EDEVRNQLAH LDTLLRQRLL PHERQDDEEV 
721:	YPRLRRQAGA PDAFAGMSRT HMEIQRQVHS LTSLRQAFGE HASGPAQRYE IQRLLHGLEA 
781:	ITRLHFAQEL EIYRSLEHE