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3.A.3.25.4
P-type ATPase with a C-terminal hemeerythrin (Hr) domain (Traverso et al., 2010). The Hr domain binds two iron ions per monomer (a diiron center) and may provide a regulatory or more direct function in iron transport (Traverso et al., 2010).

Accession Number:A0LQU2
Protein Name:Heavy metal translocating P-type ATPase
Length:794
Molecular Weight:82791.00
Species:Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [351607]
Number of TMSs:3
Substrate iron

Cross database links:

eggNOG: COG2217
HEGENOM: HBG507745
Entrez Gene ID: 4484686   
Pfam: PF00122    PF01814    PF00702   
KEGG: ace:Acel_0026   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0046872 F:metal ion binding
GO:0046873 F:metal ion transmembrane transporter activity
GO:0006754 P:ATP biosynthetic process

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRREHWLFTT STAFLALGGL AWLVHMHKAA VVLWVLATSL GLAVSLATTI KAVTKRRPTV 
61:	DVIALLALAG ALAVREPFAG AVIAVMLASG QLLEERASAR ASRTLSALVA RSPQQARRYR 
121:	TSGTTPAAGE AVDSDAEVIE EVPIDAVQVG DRVVVRPGEV VPVDGRLLTP GVFDESSLSG 
181:	ESREVEREAG EPIRSGVINI GSPVELAVTA PAAESTYARL VQLVAEAQRV ATPFVRLADR 
241:	LAVFFVPLTL AVAGSAWAFS GDAVRAVAVL VVATPCPLLL AVPIALISGV SRAAASGVVV 
301:	KGAGALEKLA RGRTILFDKT GTLTRGEPEI AEIIVADTSI DPRHLLRLAA AVEQFSAHVF 
361:	AAAFARASGR SQLSVPVASD VAEIPGCGVV GVVDGREVRI GKAHWVLDGA TPAWARRAQR 
421:	RAEMDGSSVA FIAVDGRPAG AFLLRDPVRS DAPRMIRTLR KAGLTRIVLL TGDRPDVAES 
481:	VGRVVGIDAV IADADPADKL VVVREESSVA PTIMVGDGIN DAPALAAAGA GVALAGRGAT 
541:	ASSEAADVVL VADRVDALAD AVLTARRTKR IAGQAAGTGM GLSLAAMAAA GLGLLPPAAG 
601:	ALLQEGIDLL AIALALRALL PGTRHTVGLA TADQAVAERL RAEHDVVRSV GQRLRVVADA 
661:	LAPCREDFSA LEDLVGELEA VLLPHERAEE DQLLPIVARA LRSSDVVAGL SRAHAEIEHY 
721:	VRRLRRLLTM VGGEPESDDV IEARRLLYGL HAVLDLHNAE EDEIAFALLP DAGQRNTQDQ 
781:	KRVLTSTAPT GVSE