TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.3.27.4
The Cu2+ - ATPase, CtpA. Required for assembly of periplasmic and membrane embedded copper-dependent oxidases, but not for copper tolerance (Hassani, et al. 2010). Possibly CtpA delivers Cu2+ directly to the enzymes in the membrane rather than catalyzing transmembrane transport: similar to (3.A.3.27.1).

Accession Number:Q5GCB0
Protein Name:CtpA
Length:768
Molecular Weight:80603.00
Species:rhodocyclus gelatinosus [28068]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cu2+

Cross database links:

Pfam: PF00122    PF00403    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (1)

[1] “Global regulation of photosynthesis and respiration by FnrL: the first two targets in the tetrapyrrole pathway.”  Ouchane S.et.al.   17178720

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MFEAGSETTY SGDGDRRPRP TASMSLSGFA PVQQAAPSLA AVDDPLELAR YTRWVHESDG 
61:	VRLGESALQI SGMYCAACTG ILENALRGVD GVRDARVSAA AQRATVRWDP AKTQPSALIA 
121:	AIRAAGYDAV PDAAAPAREM RRAEHRAALW RLFVASFCAM QVMMFATPSY VAGPGELSME 
181:	MRQLLNWGCW VLSIPVVLFS AGPFFRGAWR GLRAGRIGMD VPVSVGVAVT FVASTGATFD 
241:	PSGVFGHEVY FDSLTMFVSF LLAGRYLELR ARHRAAAALE GALACLPETA QRLEADGSIS 
301:	EISVQRLVAG DRVRVALGQA FPADGALIEG ATQADESLLT GESVAVEKPC GAAVVAGSVN 
361:	LGAPVTMRVE RAGADTRYEA MVSMMRDAMS QRPALARVAD RWAVPFLWAV LVLAAGAAAA 
421:	WSVVDPSRAI WVAVSVLIVT CPCALSLAAP ATMIAAAGGL ARRGVLVQRL DALEDLARAG 
481:	RLFIDKTGTL TEDRPVLATT LVLEEGMDAP ARAVSLAGWS RHPLSQALVA ALPPARHDWT 
541:	AVEERAGQGL SATDTDGREW RLGGAAFAGA PSREDVQVWL SCSGRPVAGF GFDELLRPGA 
601:	EDAVRELVAD GVRVTLLSGD VPARAARLAK RLGLDSFVGG ARPEDKLAAV AAAQRAGERV 
661:	VMVGDGVNDA PVLARADVSL AMGQGALVAR AQADAVLASN RPLDLVRARR TSARAMRIVR 
721:	QNMIWAAAYN AACIPAGLDR AGLPPWAAGL GMAGSSLFVV LNALRAGR