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3.A.3.3.2
H+ (in)/K+ (out) Mg2+-ATPase (antiporter)

Accession Number:P11718
Protein Name:ATXA aka H1A
Length:974
Molecular Weight:107479.00
Species:Leishmania donovani [5661]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate H+, K+, Mg2+

Cross database links:

Pfam: PF00690    PF00122    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0008553 F:hydrogen-exporting ATPase activity, phospho...
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0015992 P:proton transport

References (2)

[1] “Structure and expression of a tandem gene pair in Leishmania donovani that encodes a protein structurally homologous to eucaryotic cation-transporting ATPases.”  Meade J.C.et.al.   2828921
[2] “A tandem pair of Leishmania donovani cation transporting ATPase genes encode isoforms that are differentially expressed.”  Meade J.C.et.al.   2469011

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSSKKYELDA AAFEDKPESH SDAEMTPQKP QRRQSVLSKA VSEHDERATG PATDLLPPSK 
61:	GLTTEEAEEL LKKYGRNELP EKKTPSWLIY VRGLWGPMPA ALWIAIIIEF ALENWPDGAI 
121:	LFAIQIANAT IGWYETIKAG DAVAALKNSL KPTATVYRDS KWQQIDAAVL VPGDLVKLAS 
181:	GSAVPADCSI NEGVIDVDEA ALTGESLPVT MGPEHMPKMG SNVVRGEVEG TVQYTGSLTF 
241:	FGKTAALLQS VESDLGNIHV ILRRVMFSLC AISFMLCMCC FIYLLARFYE TFRHALQFAV 
301:	VVLVVSIPIA LEIVVTTTLA VGSKHLSKHK IIVTKLSAIE MMSGVNMLCS DKTGTLTLNK 
361:	MEIQEQCFTF EEGNDLKSTL VLAALAAKWR EPPRDALDTM VLGAADLDEC DNYQQLNFVP 
421:	FDPTTKRTAA TLVDRRSGEK FDVTKGAPHV ILQMVYNQDE INDEVVDIID SLAARGVRCL 
481:	SVAKTDQQGR WHMAGILTFL DPPRPDTKDT IRRSKEYGVD VKMITGDHLL IAKEMCRMLD 
541:	LDPNILTADK LPQIKDANDL PEDLGEKYGD MMLSVGGFAQ VFPEHKFMIV ETLRQRGYTC 
601:	AMTGDGVNDA PALKRADVGI AVHGATDAAR AAADMVLTEP GLSVVVEAML VSREVFQRML 
661:	SFLTYRISAT LQLVCFFFIA CFSLTPKAYG SVDPHFQFFH LPVLMFMLIT LLNDGCLMTI 
721:	GYDHVIPSER PQKWNLPVVF VSASILAAVA CGSSLMLLWI GLEGYSSQYY ENSWFHRLGL 
781:	AQLPQGKLVT MMYLKISISD FLTLFSSRTG GHFFFYMPPS PILFCGAIIS LLVSTMAASF 
841:	WHKSRPDNVL TEGLAWGQTN AEKLLPLWVW IYCIVWWFVQ DVVKVLAHIC MDAVDLFGCV 
901:	SDASGSGPIK PYSDDMKVNG FEPVKKPAEK STEKALNSSV SSASHKALEG LREDTHSPIE 
961:	EASPVNVYVS RDQK