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3.A.3.3.5
Plasma membrane H+-ATPase, TbHA1 (912 aas) (3 isoforms are present in T. brucei) (Luo et al., 2006). This and another H+-ATPase, (UniProt acc # Q388Z3; 97% identical to TbHA1) have been found to be essential for bloodstream-form Trypanosoma brucei through a genome-wide RNAi screen (Schmidt et al. 2018).

Accession Number:Q86DE0
Protein Name:TbHA1 aka P-type H+-ATPase
Length:912
Molecular Weight:100202.00
Species:Trypanosoma brucei [5691]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

Pfam: PF00690    PF00122    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0006754 P:ATP biosynthetic process
GO:0006812 P:cation transport

References (1)

[1] “Molecular characterization of Trypanosoma brucei P-type H+-ATPases.”  Luo S.et.al.   16757482

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGDTGPKGVP GTNDAGEVHK PQKPQRRQSV LSKAISEHRE GDDGSVPLVP PSKGLTSAEA 
61:	EELLLKYGRN ELPEKKTPSW LIFLRNLWGP MPIVLWIVII IQFALQHFAD GAVLLGIQLA 
121:	NALIGWYETI KAGDAVAALK NSLKPIATAY RDGTWQQIDA ALLVPGDLVK LGSGSAVPAD 
181:	CTINEGVIDV DEAALTGESL PVTMGTEHMP KMGSNVVRGE VDATVQYTGQ STFFGKTATL 
241:	LQSVEADIGS IRIILMRVMV ISSSFSFVLC LICFIYLMVN FKQKFRDALQ FAVVVLVVSI 
301:	PIALEIVVTT TLAVGSKKLS KHKIIVTRLT AIETMSGVNM LCSDKTGTLT LNKMEIQEQC 
361:	FTFEKGHDLR SLLVLSALAA KWREPPRDAL DTMVLGAADL DECDNYEQLE FVPFDPTTKR 
421:	TAATLVDKRS GEKFSVTKGA PHVIIEMVHN QDEINDSVVD IIDKLASRGI RCLSVAKTDS 
481:	AGRWHLCGIL TFLDPPRPDT KETIRRSRQY GVDVKMITGD HVLIAKEMCR MLDLDPNILT 
541:	AEKLPKVDVN DMPSDLGEKY GDMMLSVGGF AQVFPEHKFL IVEALRQRGY TCAMTGDGVN 
601:	DAPALKRADV GIAVQGATDA ARAAADMVLT DPGLSVVVDA MFVSRQVFQR MLSFLTYRIS 
661:	ATMQLVCFFF IACFSLTPHD YGIENPEFQV FYLPVMMFML ITLLNDGCLM TIGYDRVVPS 
721:	KLPQRWNIPV VFTSAIIMSV VACASSLLLL WMALDAYDEK RYPNSWFGKL NIPSLKEGKI 
781:	VTLLYLKISI SDFLTLFSSR TGGRFFFSMA PGTILLVGAV ISLVISTIAA SVWKKSSSDG 
841:	VPVEGLARGE TVADRLYPLW VWIYCILWWI VQDVVKVLTH MLMEAFDIFG CVSRASGGKE 
901:	IVYNAKSSKE PI