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3.A.3.5.1
Cu2+-ATPase (uptake)

Accession Number:P32113
Protein Name:CopA
Length:727
Molecular Weight:78388.00
Species:Enterococcus hirae [1354]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cu2+

Cross database links:

Pfam: PF00122    PF00403    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0004008 F:copper-exporting ATPase activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0006825 P:copper ion transport

References (5)

[1] “Primary structure of two P-type ATPases involved in copper homeostasis in Enterococcus hirae.”  Odermatt A.et.al.   8048974
[2] “Two trans-acting metalloregulatory proteins controlling expression of the copper-ATPases of Enterococcus hirae.”  Odermatt A.et.al.   7876197
[3] “Induction of the putative copper ATPases, CopA and CopB, of Enterococcus hirae by Ag+ and Cu2+, and Ag+ extrusion by CopB.”  Odermatt A.et.al.   8037745
[4] “Interaction of the CopZ copper chaperone with the CopA copper ATPase of Enterococcus hirae assessed by surface plasmon resonance.”  Multhaup G.et.al.   11594769
[5] “Purification and functional analysis of the copper ATPase CopA of Enterococcus hirae.”  Wunderli-Ye H.et.al.   11162579

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATNTKMETF VITGMTCANC SARIEKELNE QPGVMSATVN LATEKASVKY TDTTTERLIK 
61:	SVENIGYGAI LYDEAHKQKI AEEKQTYLRK MKFDLIFSAI LTLPLMLAMI AMMLGSHGPI 
121:	VSFFHLSLVQ LLFALPVQFY VGWRFYKGAY HALKTKAPNM DVLVAIGTSA AFALSIYNGF 
181:	FPSHSHDLYF ESSSMIITLI LLGKYLEHTA KSKTGDAIKQ MMSLQTKTAQ VLRDGKEETI 
241:	AIDEVMIDDI LVIRPGEQVP TDGRIIAGTS ALDESMLTGE SVPVEKKEKD MVFGGTINTN 
301:	GLIQIQVSQI GKDTVLAQII QMVEDAQGSK APIQQIADKI SGIFVPIVLF LALVTLLVTG 
361:	WLTKDWQLAL LHSVSVLVIA CPCALGLATP TAIMVGTGVG AHNGILIKGG EALEGAAHLN 
421:	SIILDKTGTI TQGRPEVTDV IGPKEIISLF YSLEHASEHP LGKAIVAYGA KVGAKTQPIT 
481:	DFVAHPGAGI SGTINGVHYF AGTRKRLAEM NLSFDEFQEQ ALELEQAGKT VMFLANEEQV 
541:	LGMIAVADQI KEDAKQAIEQ LQQKGVDVFM VTGDNQRAAQ AIGKQVGIDS DHIFAEVLPE 
601:	EKANYVEKLQ KAGKKVGMVG DGINDAPALR LADVGIAMGS GTDIAMETAD VTLMNSHLTS 
661:	INQMISLSAA TLKKIKQNLF WAFIYNTIGI PFAAFGFLNP IIAGGAMAFS SISVLLNSLS 
721:	LNRKTIK