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3.A.3.5.12
Chloroplast thylakoid Cu+-ATPase, PAA2/HMA8 (delivers Cu+ to the thylakoid lumen).  Degraded by the Clp protease undeer conditions of Cu+ excess (Tapken et al. 2014).

Accession Number:Q7Y051
Protein Name:Paa2
Length:883
Molecular Weight:94244.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cu+

Cross database links:

Genevestigator: Q7Y051
eggNOG: KOG0207
HEGENOM: HBG507745
Pfam: PF00122    PF00403    PF00702   
BioCyc: MetaCyc:MONOMER-14496   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0004008 F:copper-exporting ATPase activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (1)

[1] “Two P-type ATPases are required for copper delivery in Arabidopsis thaliana chloroplasts.”  Abdel-Ghany S.E.et.al.   15772282

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MASNLLRFPL PPPSSLHIRP SKFLVNRCFP RLRRSRIRRH CSRPFFLVSN SVEISTQSFE 
61:	STESSIESVK SITSDTPILL DVSGMMCGGC VARVKSVLMS DDRVASAVVN MLTETAAVKF 
121:	KPEVEVTADT AESLAKRLTE SGFEAKRRVS GMGVAENVKK WKEMVSKKED LLVKSRNRVA 
181:	FAWTLVALCC GSHTSHILHS LGIHIAHGGI WDLLHNSYVK GGLAVGALLG PGRELLFDGI 
241:	KAFGKRSPNM NSLVGLGSMA AFSISLISLV NPELEWDASF FDEPVMLLGF VLLGRSLEER 
301:	AKLQASTDMN EPLSLISTQS RLVITSSDNN TPVDSVLSSD SICINVSVDD IRVGDSLLVL 
361:	PGETFPVDGS VLAGRSVVDE SMLTGESLPV FKEEGCSVSA GTINWDGPLR IKASSTGSNS 
421:	TISKIVRMVE DAQGNAAPVQ RLADAIAGPF VYTIMSLSAM TFAFWYYVGS HIFPDVLLND 
481:	IAGPDGDALA LSLKLAVDVL VVSCPCALGL ATPTAILIGT SLGAKRGYLI RGGDVLERLA 
541:	SIDCVALDKT GTLTEGRPVV SGVASLGYEE QEVLKMAAAV EKTATHPIAK AIVNEAESLN 
601:	LKTPETRGQL TEPGFGTLAE IDGRFVAVGS LEWVSDRFLK KNDSSDMVKL ESLLDHKLSN 
661:	TSSTSRYSKT VVYVGREGEG IIGAIAISDC LRQDAEFTVA RLQEKGIKTV LLSGDREGAV 
721:	ATVAKNVGIK SESTNYSLSP EKKFEFISNL QSSGHRVAMV GDGINDAPSL AQADVGIALK 
781:	IEAQENAASN AASVILVRNK LSHVVDALSL AQATMSKVYQ NLAWAIAYNV ISIPIAAGVL 
841:	LPQYDFAMTP SLSGGLMALS SIFVVSNSLL LQLHKSETSK NSL