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3.A.3.5.13
The archaeal Cu+ efflux pump (CopA)

Accession Number:Q97UU7
Protein Name:Copper-transporting ATPase
Length:695
Molecular Weight:76330.00
Species:Sulfolobus solfataricus [2287]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Plastid1 / Multi-pass membrane protein2
Substrate Cu+

Cross database links:

HEGENOM: HBG507745
RefSeq: NP_344213.1   
Entrez Gene ID: 1452922   
Pfam: PF00122    PF00403    PF00702   
BioCyc: SSOL273057:SSO2896-MONOMER   
KEGG: sso:SSO2896   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0004008 F:copper-exporting ATPase activity
GO:0008900 F:hydrogen:potassium-exchanging ATPase activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0006825 P:copper ion transport

References (1)

[1] “The complete genome of the crenarchaeon Sulfolobus solfataricus P2.”  She Q.et.al.   11427726
Structure:
2IYE   2YJ3   2YJ4   2YJ5   2YJ6     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MMSQEQNNIT KFYVGGMACA FCASTIEKGL KKIEGVNEVK VVLESSEVFV KYDNSLVSSE 
61:	IIKKEIEKLG YYVSDRSLFS DELLKDSRRR SIISWSLTTL LGLLYFFEYY NIIFRVTIIL 
121:	LVTTNLFYIA LPIYKGASHA IGKGILNEHV LYGVAGISSY ILGIVGFLEF NKNLFGFLFI 
181:	SSLLTSLHLS AGWMGAILNN KVEKALHKVI ELRPPYAHLI NGEDVPVTKL KKGDIVIVKP 
241:	GEKIPLDGVV VDGESEVSEA IITGESEPVS KGKGDFVIGG STNGSGYLKV KITEDYNNSY 
301:	LSKIIGLVNY SKQKKSAILT FFDKVIDKIW VPLALAISII TVIAWGLYGI LIGKDLWLYG 
361:	IINGLLVSTI AYPCAIGFSS PSMALSLYEK MLHKGMIIKN SNVYEKIKEI DTIIFDKTGT 
421:	LTYGTPIVTQ FIGDSLSLAY AASVEALSSH PIAKAIVKYA KEQGVKILEV KDFKEISGIG 
481:	VRGKISDKII EVKKAENNND IAVYINGEPI ASFNISDVPR PNLKDYLEKL KNEGLKIIIL 
541:	SGDKEDKVKE LSKELNIQEY YSNLSPEDKV RIIEKLKQNG NKVLMIGDGV NDAAALALAD 
601:	VSVAMGNGVD ISKNVADIIL VSNDIGTLLG LIKNRKRLSN AIPSNVILAL TYNGIGIPLA 
661:	IFGILTMKFA MIIMILSLFS IFINSRVFVN IIGFD