TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.3.5.18
The copper resistance ATPase, CopA (Ettema et al., 2006Lübben et al., 2007; Villafane et al., 2009).

Accession Number:O32220
Protein Name:Copper-transporting P-type ATPase aka CopA
Length:802
Molecular Weight:85912.00
Species:Bacillus subtilis [1423]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cu+

Cross database links:

HEGENOM: HBG507745
RefSeq: NP_391230.2   
Entrez Gene ID: 937985   
Pfam: PF00122    PF00403    PF00702   
KEGG: bsu:BSU33500   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0005507 F:copper ion binding
GO:0004008 F:copper-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0006825 P:copper ion transport

References (7)

[1] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[2] “CopZ from Bacillus subtilis interacts in vivo with a copper exporting CPx-type ATPase CopA.”  Radford D.S.et.al.   12644235
[3] “Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon.”  Gaballa A.et.al.   14663075
[4] “Solution structure of the N-terminal domain of a potential copper-translocating P-type ATPase from Bacillus subtilis in the apo and Cu(I) loaded states.”  Banci L.et.al.   11922674
[5] “Structural basis for the function of the N-terminal domain of the ATPase CopA from Bacillus subtilis.”  Banci L.et.al.   14514665
[6] “Understanding copper trafficking in bacteria: interaction between the copper transport protein CopZ and the N-terminal domain of the copper ATPase CopA from Bacillus subtilis.”  Banci L.et.al.   12590580
[7] “Structure and Cu(I)-binding properties of the N-terminal soluble domains of Bacillus subtilis CopA.”  Singleton C.et.al.   18215122
Structure:
1JWW   1KQK   1OPZ   1OQ3   1OQ6   1P6T   2RML   2VOY     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSEQKEIAMQ VSGMTCAACA ARIEKGLKRM PGVTDANVNL ATETSNVIYD PAETGTAAIQ 
61:	EKIEKLGYHV VTEKAEFDIE GMTCAACANR IEKRLNKIEG VANAPVNFAL ETVTVEYNPK 
121:	EASVSDLKEA VDKLGYKLKL KGEQDSEAAA KKKEERKQTA RLIFSAVLSF PLLWAMVSHF 
181:	TFTSFIWVPD IFLNPWMQFA LATPVQFLIG WPFYVGAYKA LRNKSANMDV LVALGTTAAY 
241:	AYSLYLTFQS IGSHGHTDGL YYETSAILLT LILLGKLFET KAKGRSSDAI KKLMKLQAKT 
301:	ATVVRDGQEQ IIPIDEVLVN DIVYVKPGER IPVDGEVVEG RSAVDESMIT GESLPVDKNP 
361:	GDSVTGSTVN ANGFLKIKAV NVGKDTALSH IIKIVEEAQG SKAPIQRLAD QISGIFVPIV 
421:	LGIAVLTFLI WYLWAAPGDF AEAISKFIAV LVIACPCALG LATPTSIMAG SGRAAEFGIL 
481:	FKGGEHLEKT HRLDTIVLDK TGTVTNGKPR LTDAIPFGRF EEKDLLQFAA AAETGSEHPL 
541:	GEAIIAGVKD KGLEIPKLTR FEAKVGAGIL AEAGGKSILV GTRKLMESEQ VEHGALLAQM 
601:	EELEAEGKTV MLVSIDGEAA GLVAVADTIK DTSRKAVARL KELGLDVIMM TGDNRRTAEA 
661:	IAKEAGIANI IAEVLPEQKA AEIARLQKEG RQTAMVGDGI NDAPALATAD IGMAIGTGTD 
721:	IAMETADITL IRGDLNSIAD AIRMSRLTMK NIKQNLFWAL GYNSLGIPIA ALGFLAPWIA 
781:	GAAMAFSSVS VVLNALRLQK VK