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3.A.3.5.19
The Cu2+, Fe3+, Pb2+ resistance efflux pump, CopA (induced by copper and to a lesser extent by Fe3+ and Pb2+) (Sitthisak et al., 2007)

Accession Number:Q7A3E6
Protein Name:CopA
Length:802
Molecular Weight:86773.00
Species:Staphylococcus aureus (strain N315) [158879]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cu2+, Fe2+, Pb2+

Cross database links:

eggNOG: COG2217
HEGENOM: HBG507745
RefSeq: NP_375669.1   
Entrez Gene ID: 1125272   
Pfam: PF00122    PF00403    PF00702   
BioCyc: SAUR158879:SA2344-MONOMER   
KEGG: sau:SA2344   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0004008 F:copper-exporting ATPase activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0006825 P:copper ion transport

References (1)

[1] “Whole genome sequencing of meticillin-resistant Staphylococcus aureus.”  Kuroda M.et.al.   11418146

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MANTKKTTLD ITGMTCAACS NRIEKKLNKL DDVNAQVNLT TEKATVEYNP DQHDVQEFIN 
61:	TIQHLGYGVT VETVELDITG MTCAACSSRI EKVLNKMNGV QNATVNLTTE QAKVDYYPEE 
121:	TDADKLVTRI QKLGYDASIK DNNKDQTSRK AEALQHKLIK LIISAVLSLP LLMLMFVHLF 
181:	NMHIPALFTN PWFQFILATP VQFIIGWQFY VGAYKNLRNG GANMDVLVAV GTSAAYFYSI 
241:	YEMVRWLNGS TTQPHLYFET SAVLLTLILF GKYLEARAKS QTTNALGELL SLQAKEARIL 
301:	KDGNEVMIPL NEVHVGDTLI VKPGEKIPVD GKIIKGMTAI DESMLTGESI PVEKNVDDTV 
361:	IGSTMNKNGT ITMTATKVGG DTALANIIKV VEEAQSSKAP IQRLADIISG YFVPIVVGIA 
421:	LLIFIVWITL VTPGTFEPAL VASISVLVIA CPCALGLATP TSIMVGTGRA AENGILFKGG 
481:	EFVERTHQID TIVLDKTGTI TNGRPVVTDY HGDNQTLQLL ATAEKDSEHP LAEAIVNYAK 
541:	EKQLTLTETT TFKAVPGHGI EATIDHHHIL VGNRKLMADN DISLPKHISD DLTHYERDGK 
601:	TAMLIAVNYS LTGIIAVADT VKDHAKDAIK QLHDMGIEVA MLTGDNKNTA QAIAKQVGID 
661:	TVIADILPEE KAAQIAKLQQ QGKKVAMVGD GVNDAPALVK ADIGIAIGTG TEVAIEAADI 
721:	TILGGDLMLI PKAIYASKAT IRNIRQNLFW AFGYNIAGIP IAALGLLAPW VAGAAMALSS 
781:	VSVVTNALRL KKMRLEPRRK DA