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3.A.3.5.2
Cu+-, Ag+-ATPase (efflux)

Accession Number:P05425
Protein Name:CopB
Length:745
Molecular Weight:81523.00
Species:Enterococcus hirae [1354]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cu+, Ag+

Cross database links:

Pfam: PF00122    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0004008 F:copper-exporting ATPase activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0006825 P:copper ion transport

References (4)

[1] “Primary structure of two P-type ATPases involved in copper homeostasis in Enterococcus hirae.”  Odermatt A.et.al.   8048974
[2] “Cloning of the K+-ATPase of Streptococcus faecalis. Structural and evolutionary implications of its homology to the KdpB-protein of Escherichia coli.”  Solioz M.et.al.   2953719
[3] “Induction of the putative copper ATPases, CopA and CopB, of Enterococcus hirae by Ag+ and Cu2+, and Ag+ extrusion by CopB.”  Odermatt A.et.al.   8037745
[4] “Copper and silver transport by CopB-ATPase in membrane vesicles of Enterococcus hirae.”  Solioz M.et.al.   7721839

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNNGIDPENE TNKKGAIGKN PEEKITVEQT NTKNNLQEHG KMENMDQHHT HGHMERHQQM 
61:	DHGHMSGMDH SHMDHEDMSG MNHSHMGHEN MSGMDHSMHM GNFKQKFWLS LILAIPIILF 
121:	SPMMGMSFPF QVTFPGSNWV VLVLATILFI YGGQPFLSGA KMELKQKSPA MMTLIAMGIT 
181:	VAYVYSVYSF IANLINPHTH VMDFFWELAT LIVIMLLGHW IEMNAVSNAS DALQKLAELL 
241:	PESVKRLKKD GTEETVSLKE VHEGDRLIVR AGDKMPTDGT IDKGHTIVDE SAVTGESKGV 
301:	KKQVGDSVIG GSINGDGTIE ITVTGTGENG YLAKVMEMVR KAQGEKSKLE FLSDKVAKWL 
361:	FYVALVVGII AFIAWLFLAN LPDALERMVT VFIIACPHAL GLAIPLVVAR STSIAAKNGL 
421:	LLKNRNAMEQ ANDLDVIMLD KTGTLTQGKF TVTGIEILDE AYQEEEILKY IGALEAHANH 
481:	PLAIGIMNYL KEKKITPYQA QEQKNLAGVG LEATVEDKDV KIINEKEAKR LGLKIDPERL 
541:	KNYEAQGNTV SFLVVSDKLV AVIALGDVIK PEAKEFIQAI KEKNIIPVML TGDNPKAAQA 
601:	VAEYLGINEY YGGLLPDDKE AIVQRYLDQG KKVIMVGDGI NDAPSLARAT IGMAIGAGTD 
661:	IAIDSADVVL TNSDPKDILH FLELAKETRR KMIQNLWWGA GYNIIAIPLA AGILAPIGLI 
721:	LSPAVGAVLM SLSTVVVALN ALTLK