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3.A.3.5.23
Putative spirochete Cu+ ATPase (6 proteins in spirochetes)

Accession Number:Q72N56
Protein Name:Heavy-metal transporting p-type ATPase
Length:739
Molecular Weight:80619.00
Species:Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni [44275]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Peripheral membrane protein2
Substrate Cu+

Cross database links:

HEGENOM: HBG507745
RefSeq: YP_002895.1   
Entrez Gene ID: 2772684   
Pfam: PF00122    PF00403    PF00702   
KEGG: lic:LIC12982   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0004008 F:copper-exporting ATPase activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0006825 P:copper ion transport

References (1)

[1] “Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis.”  Nascimento A.L.T.O.et.al.   15028702

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKVQQELHLN EVTLDVIGMT CANCALRIEK GLKKIPGVKD VRVNFAMETA KIDFESSISK 
61:	EILMDKIDFL GYRAVVHEDI EIDGEIQKKE FKKLKVRVIV SAFLSLPLLL SMIGHFENNL 
121:	NFEYLSFLMN PWLQFVLATP IQFWIGASFY KGSFRALRNG GANMDVLVVL GTSAAYFYSV 
181:	YLTFIFNEKY IHKTANLYYE TSSVLITLIL FGKLLEHIVK GKSSKAIQSL VNLQPKKANV 
241:	IREKEIQEIP LLAVRSGDLI LVKPGESIPV DGIIEEGSST IDESMLTGES IPVEKTISNF 
301:	VYGGSLNQNG TFKFRALKVG KETLLSGIIR AVREAQGTKA PIQRIADQIS EIFVPVIVLI 
361:	SVITLCVWYF WILPSTFSVA LEKAIAVLVV ACPCALGLAT PISVLTGSGK AATMGILFRS 
421:	AEALEILHKV NAIVFDKTGT LTYGKPVLKS LESLNMTKEN NLLTLAASAE QNSEHPLSKA 
481:	IVESAKKKGL VLAIPENFET IPGGGISAIV EGNRILIGTE RLFYAKGIEL NQELNNLKRI 
541:	REEEGNTVVH LSVNGIHSAI LTLADTLKES TPATIEKLKS LGIEVYMITG DNERTARVIS 
601:	KDCGIERVLA EVLPEKKAME VKNLKSLGKV VSMVGDGIND APALAISDLG IAMGTGTDVA 
661:	MESSDLVIVN GDLNSIVNAI TISRKTVYNI RQNFFWALLY NTLGIPIAAA GFLAPWVAGG 
721:	AMALSSVSVV LNALRLQRD