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3.A.3.5.30
Copper (Cu+) exporting P-ATPase, CopA (3-D structure known to 3.2 Å; PDB# 3RFU; Gourdon et al. 2011).  The internal surface of the ATPase interacts with the copper chaparone, CopZ (Padilla-Benavides et al. 2012).  A sulfur-lined metal transport pathway has been identified (Mattle et al. 2015).  Cu+ is bound at a high-affinity transmembrane-binding site in trigonal-planar coordination with the Cys residues of the conserved CPC motif of transmembrane segment 4 (C382 and C384) and the conserved Methionine residue of transmembrane segment 6 (M717 of the MXXXS motif). These residues are also essential for transport (Mattle et al. 2015).

Accession Number:Q5X2N1
Protein Name:Putative uncharacterized protein copA1
Length:736
Molecular Weight:78247.00
Species:Legionella pneumophila (strain Paris) [297246]
Number of TMSs:8
Substrate Cu+

Cross database links:

eggNOG: COG2217
HEGENOM: HBG507745
Entrez Gene ID: 3118615   
Pfam: PF00122    PF00702   
KEGG: lpp:lpp2356   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0004008 F:copper-exporting ATPase activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process

References (1)

[1] “Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity.”  Cazalet C.et.al.   15467720
Structure:
3rfu   4bbj     

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKHDHHQGHT HSGKGHACPH EHNSPKTQQA SSKMEGPIVY TCPMHPEIRQ SAPGHCPLCG 
61:	MALEPETVTV SEVVSPEYLD MRRRFWIALM LTIPVVILEM GGHGLKHFIS GNGSSWIQLL 
121:	LATPVVLWGG WPFFKRGWQS LKTGQLNMFT LIAMGIGVAW IYSMVAVLWP GVFPHAFRSQ 
181:	EGVVAVYFEA AAVITTLVLL GQVLELKARE QTGSAIRALL KLVPESAHRI KEDGSEEEVS 
241:	LDNVAVGDLL RVRPGEKIPV DGEVQEGRSF VDESMVTGEP IPVAKEASAK VIGATINQTG 
301:	SFVMKALHVG SDTMLARIVQ MVSDAQRSRA PIQRLADTVS GWFVPAVILV AVLSFIVWAL 
361:	LGPQPALSYG LIAAVSVLII ACPCALGLAT PMSIMVGVGK GAQSGVLIKN AEALERMEKV 
421:	NTLVVDKTGT LTEGHPKLTR IVTDDFVEDN ALALAAALEH QSEHPLANAI VHAAKEKGLS 
481:	LGTVEAFEAP TGKGVVGQVD GHHVAIGNAR LMQEHGSDNA PLFEKADELR GKGASVMFMA 
541:	VDGKTVALLV VEDPIKSSTP ETILELQQSG IEIVMLTGDS KKTAEAVAGT LGIKKVVAEI 
601:	MPEDKSRIVS ELKDKGLIVA MAGDGVNDAP ALAKADIGIA MGTGTDVAIE SAGVTLLHGD 
661:	LRGIAKARRL SENTMSNIRQ NLFFAFIYNV LGVPLAAGVL YPLTGLLLSP MIAAAAMALS 
721:	SVSVIINALR LKRVTL