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3.A.3.5.32
Copper-transporting ATPase RAN1 (EC 3.6.3.4) (Protein HEAVY METAL ATPASE 7) (Protein RESPONSIVE TO ANTAGONIST 1)

Accession Number:Q9S7J8
Protein Name:Copper-transporting ATPase RAN1
Length:1001
Molecular Weight:107395.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cu+

Cross database links:

Genevestigator: Q9S7J8
eggNOG: COG2217
HEGENOM: HOG000250397
Entrez Gene ID: 834509   
Pfam: PF00122    PF00403    PF00702   
KEGG: ath:AT5G44790   

Gene Ontology

GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0005507 F:copper ion binding
GO:0005375 F:copper ion transmembrane transporter activity
GO:0004008 F:copper-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0060003 P:copper ion export
GO:0009873 P:ethylene mediated signaling pathway
GO:0010119 P:regulation of stomatal movement

References (3)

[1] “Responsive-to-antagonist 1, a Menkes/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis.”  Hirayama T.et.al.   10319818
[2] “Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones.”  Asamizu E.et.al.   10048488
[3] “Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.”  Tabata S.et.al.   11130714
Structure:
3DXS     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAPSRRDLQL TPVTGGSSSQ ISDMEEVGLL DSYHNEANAD DILTKIEEGR DVSGLRKIQV 
61:	GVTGMTCAAC SNSVEAALMN VNGVFKASVA LLQNRADVVF DPNLVKEEDI KEAIEDAGFE 
121:	AEILAEEQTQ ATLVGQFTIG GMTCAACVNS VEGILRDLPG VKRAVVALST SLGEVEYDPN 
181:	VINKDDIVNA IEDAGFEGSL VQSNQQDKLV LRVDGILNEL DAQVLEGILT RLNGVRQFRL 
241:	DRISGELEVV FDPEVVSSRS LVDGIEEDGF GKFKLRVMSP YERLSSKDTG EASNMFRRFI 
301:	SSLVLSIPLF FIQVICPHIA LFDALLVWRC GPFMMGDWLK WALVSVIQFV IGKRFYVAAW 
361:	RALRNGSTNM DVLVALGTSA SYFYSVGALL YGAVTGFWSP TYFDASAMLI TFVLLGKYLE 
421:	SLAKGKTSDA MKKLVQLTPA TAILLTEGKG GKLVGEREID ALLIQPGDTL KVHPGAKIPA 
481:	DGVVVWGSSY VNESMVTGES VPVSKEVDSP VIGGTINMHG ALHMKATKVG SDAVLSQIIS 
541:	LVETAQMSKA PIQKFADYVA SIFVPVVITL ALFTLVGWSI GGAVGAYPDE WLPENGTHFV 
601:	FSLMFSISVV VIACPCALGL ATPTAVMVAT GVGATNGVLI KGGDALEKAH KVKYVIFDKT 
661:	GTLTQGKATV TTTKVFSEMD RGEFLTLVAS AEASSEHPLA KAIVAYARHF HFFDESTEDG 
721:	ETNNKDLQNS GWLLDTSDFS ALPGKGIQCL VNEKMILVGN RKLMSENAIN IPDHVEKFVE 
781:	DLEESGKTGV IVAYNGKLVG VMGIADPLKR EAALVVEGLL RMGVRPIMVT GDNWRTARAV 
841:	AKEVGIEDVR AEVMPAGKAD VIRSLQKDGS TVAMVGDGIN DSPALAAADV GMAIGAGTDV 
901:	AIEAADYVLM RNNLEDVITA IDLSRKTLTR IRLNYVFAMA YNVVSIPIAA GVFFPVLRVQ 
961:	LPPWAAGACM ALSSVSVVCS SLLLRRYKKP RLTTVLKITT E