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3.A.3.5.37
Copper exporting ATPase, ATP7 of 1254 aas and 10 - 12 TMSs.  DmATP7 is the sole Drosophila melanogaster ortholog of the human MNK and WND copper transporters. A regulatory element drives expression in all neuronal tissues examined and demonstrates copper-inducible, Mtf-1-dependent expression in the larval midgut. Thus, an important functional role for copper transport in neuronal tissues is implied. Regulation of DmATP7 expression is not used to limit copper absorption under toxic copper conditions. The protein localizes to the basolateral membrane of DmATP7 expressing midgut cells, supporting a role in export of copper from midgut cells (Burke et al. 2008).

Accession Number:Q9VYT4
Protein Name:ATP7, isoform B
Length:1254
Molecular Weight:136082.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1
Substrate Copper ions

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPSDERVEAT MSTVRLPIVG MTCQSCVRNI TEHIGQKSGI LGVRVILEEN AGYFDYDPRQ 
61:	TDPARIASDI DDMGFECSYP GDAADPPETP ASAWTNIRVV GMTCQSCVRN IEGNIGTKPG 
121:	IHSIEVQLAA KNARVQYDPA QYDPAQIAEL IDDMGFEASV QEPRSPSQSP SPAPASSPKK 
181:	RATPTPPPPS YAQNGSAVAI PVEQELLTKC FLHIRGMTCA SCVAAIEKHC KKIYGLDSIL 
241:	VALLAAKAEV KFNANVVTAE NIAKSITELG FPTELIDEPD NGEAEVELEI MGMTCASCVN 
301:	KIESHVLKIR GVTTASVTLL TKRGKFRYIT EETGPRSICE AIEALGFEAK LMTGRDKMAH 
361:	NYLEHKEEIR KWRNAFLVSL IFGGPCMVAM IYFMLEMSDK GHANMCCLVP GLSMENLVMF 
421:	LLSTPVQFFG GFHFYVQSYR AIKHGTTNMD VLISMVTTIS YVYSVAVVIA AVLLEQNSSP 
481:	LTFFDTPPML LIFISLGRWL EHIAKGKTSE ALSKLLSLKA ADALLVEISP DFDIISEKVI 
541:	SVDYVQRGDI LKVIPGAKVP VDGKVLYGHS SCDESLITGE SMPVAKRKGS VVIGGSINQN 
601:	GVLLVEATHT GENTTLAQIV RLVEEAQTSK APIQQLADRI AGYFVPFVVV VSSITLIAWI 
661:	IIGFSNPNLV PVAMEHKMHM DQNTIIVSYA FKCALSVLAI ACPCALGLAT PTAVMVATGT 
721:	GAINGVLVKG ATALENAHKV KTVVFDKTGT ITHGTPMTSK VTLFVTAQVC SLARALTIVG 
781:	AAEQNSEHPI ASAIVHFAKD MLNVGATPQA GSFGKSSHFQ AVPGCGIRVT VSNYEQTLRQ 
841:	ACNADRIINY ENLHRTHPQG SVPVDNGASI EHLLPQRSVR KSMELNNQQL LSDLVLEPEE 
901:	ELLTDQKIID SPEILVLIGN REWMERNAIE VPLEISDCMT HEERKGHTAV LCALNGQLVC 
961:	MFAVSDMVKP EAHLAVYTLK RMGIDVVLLT GDNKNTAASI AREVGIRTVY AEVLPSHKVA 
1021:	KIQRIQANGI RVAMVGDGVN DSPALAQADV GITIAAGTDV AAEASDIVLM RNDLLDVVAC 
1081:	LDLSRCTVRR IRYNFFFASM YNLLGIPLAS GLFAPYGFTL LPWMASVAMA ASSVSVVCSS 
1141:	LLLKMYRKPT AKTLRTAEYE AQLAAERASG SEDELDKLSL HRGLDDLPEK GRMPFKRSST 
1201:	SLISRIFMHD YGNITSPDAK YGEGLLDPEE QYDGRTKIVR SRFHANDSTE LQKL