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3.A.3.6.1
Zn2+-, Cd2+-, Pb2+-ATPase (efflux).  The enzyme from S. aureus strain 17810R, of 726 aas, functions as a Cd2+:H+ antiporter, using both the pmf and ATP hydrolysis to drive Cd2+ expulsion (Tynecka et al. 2016).

Accession Number:P20021
Protein Name:CadA
Length:727
Molecular Weight:78812.00
Species:Staphylococcus aureus [1280]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate H+, Cd2+, Zn2+, Pb2+

Cross database links:

Pfam: PF00122    PF00403    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0005524 F:ATP binding
GO:0008551 F:cadmium-exporting ATPase activity
GO:0005261 F:cation channel activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport
GO:0046686 P:response to cadmium ion

References (1)

[1] “Cadmium resistance from Staphylococcus aureus plasmid pI258 cadA gene results from a cadmium-efflux ATPase.”  Nucifora G.et.al.   2524829

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSEQKVKLME EEMNVYRVQG FTCANCAGKF EKNVKKIPGV QDAKVNFGAS KIDVYGNASV 
61:	EELEKAGAFE NLKVSPEKLA NQTIQRVKDD TKAHKEEKTP FYKKHSTLLF ATLLIAFGYL 
121:	SHFVNGEDNL VTSMLFVGSI VIGGYSLFKV GFQNLIRFDF DMKTLMTVAV IGATIIGKWA 
181:	EASIVVILFA ISEALERFSM DRSRQSIRSL MDIAPKEALV RRNGQEIIIH VDDIAVGDIM 
241:	IVKPGEKIAM DGIIVNGLSA VNQAAITGES VPVSKAVDDE VFAGTLNEEG LIEVKITKYV 
301:	EDTTITKIIH LVEEAQGERA PAQAFVDKFA KYYTPIIMVI AALVAVVPPL FFGGSWDTWV 
361:	YQGLAVLVVG CPCALVISTP ISIVSAIGNA AKKGVLVKGG VYLEKLGAIK TVAFDKTGTL 
421:	TKGVPVVTDF EVLNDQVEEK ELFSIITALE YRSQHPLASA IMKKAEQDNI PYSNVQVEEF 
481:	TSITGRGIKG IVNGTTYYIG SPKLFKELNV SDFSLGFENN VKILQNQGKT AMIIGTEKTI 
541:	LGVIAVADEV RETSKNVIQK LHQLGIKQTI MLTGDNQGTA NAIGTHVGVS DIQSELMPQD 
601:	KLDYIKKMQS EYDNVAMIGD GVNDAPALAA STVGIAMGGA GTDTAIETAD IALMGDDLSK 
661:	LPFAVRLSRK TLNIIKANIT FAIGIKIIAL LLVIPGWLTL WIAILSDMGA TILVALNSLR 
721:	LMRVKDK