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3.A.3.6.10
The Cd2+, Zn2+, Co2+ resistance ATPase, CadA (YvgW)

Accession Number:O32219
Protein Name:CadA aka YvgW
Length:702
Molecular Weight:75405.00
Species:Bacillus subtilis [1423]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cd2+, Zn2+, Co2+

Cross database links:

HEGENOM: HBG507745
RefSeq: NP_391229.2   
Entrez Gene ID: 936034   
Pfam: PF00122    PF00403    PF00702   
BioCyc: SUBTI:BSU33490-MONOMER   
KEGG: bsu:BSU33490   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0008551 F:cadmium-exporting ATPase activity
GO:0005261 F:cation channel activity
GO:0046872 F:metal ion binding
GO:0016463 F:zinc-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0006824 P:cobalt ion transport
GO:0006825 P:copper ion transport
GO:0046686 P:response to cadmium ion
GO:0006950 P:response to stress
GO:0006829 P:zinc ion transport

References (5)

[1] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[2] “Tn10 insertional mutations of Bacillus subtilis that block the biosynthesis of bacilysin.”  Yazgan A.et.al.   11267663
[3] “Investigation of the yvgW Bacillus subtilis chromosomal gene involved in Cd(2+) ion resistance.”  Solovieva I.M.et.al.   11934502
[4] “Bacillus subtilis CPx-type ATPases: characterization of Cd, Zn, Co and Cu efflux systems.”  Gaballa A.et.al.   12779235
[5] “Sporulation-specific expression of the yvgW (cadA) gene and the effect of blockage on spore properties in Bacillus subtilis.”  Irigul O.et.al.   16901659

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRLVKQEYVL DGLDCSNCAR KIENGVKGIK GINGCAVNFA ASTLTVSADG KEEQWVTNKV 
61:	EKKVKSIDPH VTVRQKHIKK SADDGYRNRM VNMLIRMAAA VILGAAAYLV QSGTIEFFLF 
121:	LGAYLIIGGD IIIRAVKNII RGQVFDEHFL MALATIGAFL IQQYPEGVAV MLFYQIGELF 
181:	QGAAVSRSRK SISALMDIRP DYANLKTKNG IEQVSSEDVQ TGDIIVVNPG ESIPLDGKVV 
241:	QGSAMVDTSA LTGESVPRKA AEGQDVMSGF INQNGVLHIE VTKGYQESAV SKILDLVQNA 
301:	SSRKARTENF ITKFAKYYTP AVVIIAVLLA FVPPLVLSGA ALSDWVYRAL IFLVISCPCA 
361:	LVVSIPLGFF GGIGAASKAG VLVKGSNYLE ALNQVKYAVF DKTGTLTKGS FEVTEIKPAE 
421:	GFTKDRLLEA AAYAELHSQH PIAESVRKAY GKMLSSDEIE SYEEISGHGI FAKVNGTEIL 
481:	AGNKKLMERE QIEDVPDENA GTIVHVAVDQ RYAGAIIIAD EIKEDAAQAV ADLKSLGIKQ 
541:	TAMLTGDSKQ TGEAVGKQLG IGEVYAELLP QDKVAQVEAL EAKLLPSEKL IFVGDGINDT 
601:	PVLARADIGV AMGGLGSDAA VEAADIVLMT DQPSKIAEAI RIAKRTRRIV WQNIGFALGV 
661:	KAIFLILGAF GIATMWEAVF SDVGVTLLAV ANAMRVMRLK NK