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3.A.3.6.13
The heavy metal efflux pump, AztA (exports Zn2+, Cd2+, Pb2+; has two adjacent heavy metal binding domains (Liu et al., 2007)

Accession Number:Q8ZS90
Protein Name:AztA
Length:879
Molecular Weight:94954.00
Species:Anabaena sp. (strain PCC 7120) [103690]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Secreted1
Substrate Zn2+, Cd2+, Pb2+

Cross database links:

eggNOG: COG2217
HEGENOM: HBG507745
RefSeq: NP_478269.1   
Entrez Gene ID: 1103431   
Pfam: PF00122    PF00403    PF00702   
BioCyc: NSP103690:ALR7622-MONOMER   
KEGG: ana:alr7622   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0046872 F:metal ion binding
GO:0046873 F:metal ion transmembrane transporter activity
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (1)

[1] “Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120.”  Kaneko T.et.al.   11759840

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MITIVQLNSC SIVVLEYWQL TFCLNSKAAM TQTPSLKTQT LQVGGMDCGS CAKTIEVALQ 
61:	QLHGVTEATV NFTTGKARVS YDAEVLSEKS IYNQIKGLGY TIEQSHQAQS HQQSHSCGGE 
121:	HDHDHQNHDH NVDIVSLQTL QLQISGMDCG SCAKTIEAGV QKIIGVQEAS VSFASERLHI 
181:	SYDPQLVNEK TIYDRIQDLG YTVEEGVETS SNHHTDACGH DHEHHHDHDY SHNHEHSQPI 
241:	NKSKQKQKSD LTSWRFWIEN RRGQSVILAG IGLVLGLLTQ YLVLPIWIAR AFYGIGIVIA 
301:	GYPIARAGLF ELRLRRADMN LLMTISVIGA VILGDWFEGG LVVFLFSLGT TLQVFTFGRT 
361:	RNAIRSLMDL TPPTATVKRG NQEFTVPVES IQLGEILTIR PGGRVALDGV VVSGNSAIDQ 
421:	SPITGESIPE DKDVGDTVFA GTLNQTGFLE VKVTHTSSDT TVAKIINLVE QAQESRAPSQ 
481:	QWVDKFAQVY TPIVILAAIA IALIPPLAFA QPFNVWLYRA LVMLVIACPC ALVISTPVSI 
541:	VSAIGAATRR GVLFKGGNAL ETAGHLTTLA FDKTGTITQG LPIVQQVYDL GVVSGDMVLL 
601:	LAASLEQKSE HPLAKAIVVK AQELGLELET PLNFTALPGK GIQANFGEQL YLVGNRRLFS 
661:	DQGICLSDEA ESLLTEIEQF GQIPVLVGTN GGLLGAIALS DGIRLEATEA LRQLQRVGLK 
721:	RLVMLTGDRA SVAKQIAQQV GITEYQAELL PEDKLQAIQQ LRRHGVVGMV GDGINDAPAL 
781:	ATADISFAVG GIDIALETAD VVLVGSDLRQ LAYAVDLSRR TVSVIQQNVV FSLVTKALFL 
841:	LLGTFGFVGL AIAVLADTGT SLLVTANGMR LFKTKTLKN