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3.A.3.6.15
The heavy metal transporter A (HmtA) mediates uptake of copper and zinc but not of silver, mercury, or cadmium (Lewinson et al., 2009).

Accession Number:Q9I147
Protein Name:Cation-transporting P-type ATPase aka FUPA34a
Length:661
Molecular Weight:68750.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Secreted1
Substrate Heavy metal cations, copper, zinc

Cross database links:

HEGENOM: HBG507745
RefSeq: NP_251125.1   
Entrez Gene ID: 882849   
Pfam: PF00122    PF00702   
BioCyc: PAER208964:PA2435-MONOMER   
KEGG: pae:PA2435   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0046872 F:metal ion binding
GO:0046873 F:metal ion transmembrane transporter activity
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSEPTAHGSH GGCAHHHHHL PFGGGLLSRD EQRRAARQLS LAMLALGLLL LGLAWRWLAA 
61:	DQAGVSQILL GVASLLVALP VARSAWDSLR HPSLHGVTDQ LIALAMLGAW ASGDLLTAAL 
121:	LPIIMIFGHV LEERSVIGSQ EAIAALGELT RSHARRIEAD GSLSEVDNAS LRPGDQVEVR 
181:	AGDRVPADGR VLQGQASLDT APITGESVPL EVAPGMEVYG GAINLDGLLR IEITRTGEAS 
241:	TLGKVIGLMQ QAERAKPPIT RLLERYAGQY MLLVLLIAAV TWFVTNDAQA MLAVLVAACP 
301:	CALVLSAPAT AIAGIAVAAR HGILIRSSAF LEELADLTSL VVDKTGTLTH GSLRLQALRL 
361:	ADAAEEASVL RLAASLGAAS SHPVSRALAA LAAHDAYHPL SDIRERQGFG VVARTAAGEA 
421:	ALGRPELFQQ LGIDASEVPE HEGPIAGIAL DGRFLGWLLL ADSVRAEAAE ALADLRELGL 
481:	GRQLLLTGDR RAVADAVAKQ VGIRQLVAQA LPEDKLRQVG AEIGSGFRPM VVGDGINDSL 
541:	ALKAGVVGVA MGAGGADIAL ASADIVLIGS DLRRLGTCVR LSRQCRRTLQ VNVAIGLGWT 
601:	LAIVAAAAFG LLGAAGAMVA ALLHNLSTLL VLGNAGRLLR FEEPLGQPRP AVEGREEEGT 
661:	P