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3.A.3.6.16
The putative heavy metal ATPase, Mac1

Accession Number:Q8TJZ4
Protein Name:Cadmium efflux ATPase
Length:647
Molecular Weight:69309.00
Species:Methanosarcina acetivorans [2214]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Heavy metal cations

Cross database links:

HEGENOM: HBG507745
RefSeq: NP_618507.1   
Entrez Gene ID: 1475525   
Pfam: PF00122    PF00702   
BioCyc: MACE188937:MA3632-MONOMER   
KEGG: mac:MA3632   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0005261 F:cation channel activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (1)

[1] “The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.”  Galagan J.E.et.al.   11932238

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MVDTMTKNAY KNSKGKNIRS LITRYQDFLL DPGTLFTMAS GLILIIAIVA YPQNMLSDSN 
61:	ATDEGNWLYL LSALIGSSFI WWSAYQGIKE RDFTADIPVT IATIAAIAIG QYSAAAVVAV 
121:	LLLLGGMLEE LVSARAGKAL ESLAKLLPDR VTVRRDGHDT VISLEDVQVG DTILVKSGER 
181:	IAVDGTVLSG TASVNQAAIT GESLPVDKQS GDTVFAGTLN ETGAMEILAT KVGKETTLGQ 
241:	IHRLIEEAQT QKPKIERLLN RHAKVYTPTA IILGGLLWWW SGDLTRAITM LIVFCPCVMV 
301:	LATPTALVAS VGNAALRGNL IKKGATVESM ARIDTVIFDK TGTLTHGEPK LSGIIPLKNN 
361:	DENDLLLLAA IAEKFSEHPL GKAVVRAAEE KGFSVPDPES FESVSGVGIK VKTSGKNIFI 
421:	GRPKQVSGLN FAISNEVEEN IEKQSQSGHN TVLMGIDNEI VGLLTFEDKI RPESKKSVKD 
481:	LHKLGIKTIM VTGDSKAVAE RIAKILGIDE VHAEVMPQEK VEIVKRLQLE GHKVIFVGDG 
541:	VNDGPALVTA DVGVAMGLTG TDVAIETAEV GLLSDDLLKI SYLINISRKA IKTIWQNVAF 
601:	SLSVLSVAVA LTIPGILTPI TGALLHELSS IPVIMNSARL ITYEPKD