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3.A.3.6.25
Cd2+/Zn2+/Co2+ export ATPase, ZntA, of 904 aas and 8 TMSs. Expression of the zntA gene is inducible by all three metal ions, with Cd2+ being the most potent, mediated by the MerR-like regulator, ZntR (Chaoprasid et al. 2015). zntA and zntR mutants were highly sensitive to CdCl2 and ZnCl2, and less sensitive to CoCl2. Inactivation of zntA increased the accumulation of intracellular cadmium and zinc and conferred hyper-resistance to H2O2. Thus, ZntA and its regulator, ZntR, are important for controlling zinc homeostasis and cadmium and cobalt detoxification. The loss of either the zntA or zntR gene did not affect the virulence of A. tumefaciens in Nicotiana benthamiana (Chaoprasid et al. 2015).

Accession Number:F7U6A3
Protein Name:P type cation (Metal) transporter, ATPase component
Length:904
Molecular Weight:94906.00
Species:Agrobacterium tumefaciens F2 [1050720]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1
Substrate Co2+, Zn2+, Cd2+

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FASTA formatted sequence
1:	MNISTRGNLN GQSEDLTFTV GGMDCGSCAA KIETALSRLP GVADVKVSVA RERLNLSLAD 
61:	NKTSVEKIED TLRKLGFKPA LLPQDKAPRE KAAAEHHEHA HDHGDDHDHS SCGGHHPAEA 
121:	APSVEQNNAL TFSVGGMDCG SCAAKIETAL SRLPGVADVK VSVARERLNL SLAESKTPVE 
181:	KIEDTLRKLG FKPALLPQEK SAREKVDDHG HDHGSCSGHD HNHDHSGHDH SGHDHSAHDH 
241:	SDHDHANCGG HDHDHAKHSH EKAQTATATQ SAEVGHAHGA DEKGVWWRTA KARNTFTGTL 
301:	LVAVAYAAEL SFPSWGSYAF IIATLVTLFP IARNAFNAAR FGAIFTIEML MTIAAIGAIF 
361:	IGEAEEAAIV VLLFSVGELL EGFAAARARS GIKALGSLLP KTALVEENGS LRQVAADQVR 
421:	IGQVVVARPG DRIAADGVVM EGESSVDESP MTGESIPVAK EKGARVFAGS INHDGSLRIR 
481:	VDRAPEDNTI ARIITLVEEA QDARAPTERF IQNFSRYYMP LIVAISVLTI IVPPLAGLGD 
541:	WDTWIYRGLA LLLIGCPCAL VISVPAAIAS SLSAAARHGM LVKGGAVIEM LARTETVAFD 
601:	KTGTLTLGEP VVTDVVALDG DENTLIAQAA TIEHESSHPL ARAIVNHAEK AGVKPLPGSN 
661:	IKAISGRGMQ GTVGGKDLFI GAPRFATEVG TLSKDLADRI SALESEGKTV AVVMAGGAAS 
721:	GLFAMRDEPR KDAAEGIKAL KDMGISSLML SGDNARTARA IGNKLGLEAR GELLPQNKVE 
781:	EIRKLAAQKT VVMVGDGIND APALAAASVG VAIGSGTDVA MEAADAALMR NNVGDAARLI 
841:	GLSRATMANI RQNVTIALGL KAVFLVTTVT GLSGLWLAVF ADTGATVLVT ANAMRLLGYF 
901:	KKSA