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3.A.3.6.27
Transition metal efflux ATPase of 829 aas and 6 TMSs, CzcP.  Exports Zn2+, Cd2+ and Co2+ efficiently (Scherer and Nies 2009). The side chains of Met254, Cys476, and His807 contribute to Cd2+, Co2+, and Zn2+ binding and transport (Smith et al. 2017).

Accession Number:Q1LAJ7
Protein Name:CzcP cation efflux P1-ATPase
Length:829
Molecular Weight:86994.00
Species:Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) [266264]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1
Substrate Co2+, Cd2+, Zn2+

Cross database links:

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTEKLRLDIP VLLPGLPDSS DPCVERLLSE LRGKEGVEAA HIKTANVDSD SQICVHYDPA 
61:	AISLARIREL VTSTGAVISS RFGHVLWQLK GVWHERRART VASQLRALPG VIEAEVSASG 
121:	IARVEFDNDR ISAAGIEQAL SKRGLAPVEI GARKSGHADH EHREGVKDHA HGEGEGHEAH 
181:	AHGSVFGPNT ELIFSLICGA LLGLGFAVGK LFGSLPAWIP VAFFVGAYFF GGFYTVREAI 
241:	ENLRLKKFEI DTLMLVAAAG AAALGAWAEG ALLLFLFSLG HGLEHYAMGR AKRAIEALAA 
301:	LAPATASVRR EGEVREVPVE ELQVGDVVVV RPNERLPADG FLVKGASAVN QAPVTGESIP 
361:	VDKQPVDDAA AARRKPDAVG AVSRVFAGTI NGAGAIEVEV TRLSTDSALA KVVKMVNEAE 
421:	AQKSPSQRFT EKFERIFVPA VLVLAVLLLF AGLVINEPFS ATFYRAMAVL VAASPCALAI 
481:	ATPSAVLSGV ARAARGGVLI KGGAPLENLG SLKAIAFDKT GTLTEGRPRI TDVMVAEGVA 
541:	EAELLSVAVA VESLSDHPLA AAIARDGRKR LEGSSIPEAS HLQSLTGRGV TATLCGKTVW 
601:	IGKPDMFGAD GIAPLSESMA SAVQTLRSTG RTTMIVRQGD RDLGAIGLMD TPRASARAAL 
661:	EALRRLGITR MIMISGDHQR AAEAVAKDVG IDEAWGDLMP EDKVKAIQTL RAEAKVAMVG 
721:	DGVNDAPAMA NATVGIAMGA AGSDVALETA DVALMADDLQ HLPFVVGLSR HTRAIILQNV 
781:	YISLGVVAFL LPATILGLGI GPAVAMHEGS TLIVVFNALR LLAYRDKSP