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3.A.3.6.3
Cd2+-, Zn2+, Co2+-ATPase (efflux)

Accession Number:Q59465
Protein Name:HMCT aka CadA aka HP0791
Length:686
Molecular Weight:75012.00
Species:Helicobacter pylori (Campylobacter pylori) [210]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Co2+, Zn2+, Cd2+

Cross database links:

HEGENOM: HBG507745
DIP: DIP-3082N
RefSeq: NP_207584.1   
Entrez Gene ID: 899347   
Pfam: PF00122    PF00403    PF00702   
KEGG: hpy:HP0791   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0008551 F:cadmium-exporting ATPase activity
GO:0005261 F:cation channel activity
GO:0046872 F:metal ion binding
GO:0016463 F:zinc-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (4)

[1] “Cloning and membrane topology of a P type ATPase from Helicobacter pylori.”  Melchers K.et.al.   8550601
[2] “The complete genome sequence of the gastric pathogen Helicobacter pylori.”  Tomb J.-F.et.al.   9252185
[3] “Helicobacter pylori cadA encodes an essential Cd(II)-Zn(II)-Co(II) resistance factor influencing urease activity.”  Herrmann L.et.al.   10417643
[4] “Membrane topology of CadA homologous P-type ATPase of Helicobacter pylori as determined by expression of phoA fusions in Escherichia coli and the positive inside rule.”  Melchers K.et.al.   10577484

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQEYHIHNLD CPDCASKLER DLNELDYVKK AQINFSTSKL FLDTSDFEKV KAFIKQNEPH 
61:	LSLSFKEATE KPLSFTPLII TIMVFLGAIL ILHLNPSPLI EKAMFFVLAL VYLVSGKDVI 
121:	LGAFRGLRKG QFFDENALML IATIAAFFVG AYEESVSIMV FYSAGEFLQK LAVSRSKKSL 
181:	KALVDVAPNL AYLKKGDELV SVAPEDLRVN DIVVVKVGEK VPVDGVVVKG ESLLDERALS 
241:	GESMPVNVSE NSKVLGGSLN LKAVLEIQVE KMYKDSSIAK VVDLVQQATN EKSETEKFIT 
301:	KFSRYYTPSV LFIALMIAVL PPLFSMGSFD EWIYRGLVAL MVSCPCALVI SVPLGYFGGV 
361:	GAASRKGILM KGVHVLEVLT QAKSIAFDKT GTLTKGVFKV TDIVPQNGHS KEEVLHYASC 
421:	SQLLSTHPIA LSIQKACEEM LKDDKHQHDI KNYEEVSGMG VKAQCHTDLI IAGNEKMLDQ 
481:	FHIAHSPSKE NGTIVHVAFN QTYVGYIVIS DEIKDDAIEC LRDLKVQGIE NFCILSGDRK 
541:	SATESIAQTL GCEYHASLLP EEKTSVFKTF KERYKAPAIF VGDGINDAPT LASADVGIGM 
601:	GKGSELSKQS ADIVITNDSL NSLVKVLAIA KKTKSIIWQN ILFALGIKAV FIVLGLMGVA 
661:	SLWEAVFGDV GVTLLALANS MRAMRA