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3.A.3.6.4
Pb2+-ATPase (efflux), PbrA.  Mediates resistance to Pb2+, Cd2+ and Zn2+.  Lead resistance is facilitated by the phosphatase, PbrB, possibly by allowing complexation of the Pb2+ by phosphate in the periplasm (Hynninen et al. 2009).
 

Accession Number:Q58AJ6
Protein Name:P-type ATPase involved in Pb(II) resistance PbrA
Length:799
Molecular Weight:84174.00
Species:Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [266264]
Number of TMSs:8
Substrate Pb2+

Cross database links:

eggNOG: COG2217
HEGENOM: HBG507745
Entrez Gene ID: 3170369    3170514    3170525    4036385   
Pfam: PF00122    PF00403    PF00702   
KEGG: rme:Rmet_5947   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0005261 F:cation channel activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (2)

[1] “The czc operon of Alcaligenes eutrophus CH34: from resistance mechanism to the removal of heavy metals.”  Diels L.et.al.   7766206
[2] “Cloning and functional analysis of the pbr lead resistance determinant of Ralstonia metallidurans CH34.”  Borremans B.et.al.   11544228

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSECGSKGCG CASVATRNPE PSTVGAGLKQ ARYRIENMDC PTEEALIRDK LAKLPGVGGL 
61:	EFNLMQRTLA VSHQMASPGP IEEALSAIGM RAVRMDEATP LQNTVLAIHQ MDCPTEEALI 
121:	RSKLAGIPGV ASLEFNLVQR TLHVWHAADT LSHVLTALKS LGFDAEVRSA GAPAAAEAPG 
181:	PARTNWWPLA VSGVAATLAE VVYWLHGGNH WGVVALALAA IFTGGLTTYK RGWIALRNRN 
241:	LNMNALMSIA VTGAMLIGHW PEAAMVMVLF ALAEVIEAKS LDRARNAIRG LMDLAPDTAL 
301:	IQQADGSWAE VDAKAVAVGS RIRVKPGERI ALDGQVIEGR STVNQAPITG ESLPVEKIEG 
361:	DPVFAGTINE SGSFEFRVTA AANASTLARI IHAVEAAQGS RAPTQRFVDQ FARLYTPVVF 
421:	AVALAVAVLP PLVFGGPWLD WIYKALVLLV IACPCALVIS TPVSIVSGLA AAARHGILIK 
481:	GGVYLEEGRK LKWLALDKTG TITHGKPALT DFVVWGDANP ATSRLLAASL AARSDHPVSL 
541:	AVARAAEGEG LIPCDVADFA ALPGRGVRGS VDDHSYHLGN HRLVEELGVC SPELESRLAA 
601:	LEAEGKTVVM LVGPEGVQAL FAVADTVKEN SRQAIADLHT LGVKTMMLTG DNPHTATAIA 
661:	GQVGIDRSRG NLLPEDKLRE VEQLSTDGKT GMVGDGINDA PALARADIGF AMGAAGTDTA 
721:	IETADVALMD DDLRKLPTFV RLSRATASVL KQNIALALGI KAVFLVLTFT GQATMWMAVF 
781:	ADMGASLLVV GNGLRLLRR