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3.A.3.6.5
Mono- and divalent heavy metal (Cu+, Ag+, Zn2+, Cd2+) ATPase, Bxa1. bxa1 gene expression is induced by all four heavy metal ions (Tong et al., 2002). The His-rich domain is essential for both monovalent (Ag+ and Cu+) and divalent ( Cd2+ and Zn2+) metal tolerance (Nakakihara et al. 2009).

Accession Number:Q8L158
Protein Name:Bxa1
Length:660
Molecular Weight:70808.00
Species:Oscillatoria brevis [177969]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Secreted1
Substrate Cd2+, Zn2+, Ag+, Cu+

Cross database links:

Pfam: PF00122    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0005261 F:cation channel activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (1)

[1] “A novel histidine-rich CPx-ATPase from the filamentous cyanobacterium Oscillatoria brevis related to multiple-heavy-metal cotolerance.”  Tong L.et.al.   12193618

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQKAKSSDSG CCSHDAHHEH SHENHNHDHD HGHDHGNGDF NLKQELIPVI SVVLLFIGGL 
61:	IFEEKLHNTP YSIAEYLVFI PAYLLSGWNV LTSAGRNILR GRVFDENFLM TVATLGAVAI 
121:	HKLPEAVGVM LFFKIGELFQ EFAVGRSRQS IKSLLEIRPD SANLKENGDI KKVSPETVAV 
181:	GDIILVKPGE KIPLDGEIID GNSQIDTSAL TGESVPRTVK VGETVLAGTI NQTGVLTVKV 
241:	TKIFGESSIS RILELVENAR SKKAETEKFI SKFASYYTPF VVFASLGVAL IPPLFISGAT 
301:	NADRLLWVYR ALVLLVISCP CGLVISIPLG YFGGIGGAAK RGILVKGSTF LDTLTAVKTV 
361:	VLDKTGTLTK GVFKVAQIVP QNGFSQSDLM AMAAKVESQS NHPVAKSILE AYGGKIDSSE 
421:	VTDYEEIAGH GILAKVNNQI VLAGNDRLLH RENIPHDVCN AEGTVVHLAV DNRYAGYILI 
481:	ADELKDDAVQ AIRDLKKLGV ERIVMLTGDN QAVADSVARK LGLDSYIAEL LPEGKVEAIE 
541:	KLISQSKKGD KIVFVGDGIN DAPVLARADV GIAMGGLGSD AAIETADIVI MADAPSKVAE 
601:	AIQIARKTHN IVWQNIIFAM SVKAIFIALG AFGLATMWEA VFADVGVALA AIFNATRVLK