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3.A.3.6.6
Chloroplast envelope Cu+-ATPase, HMA1 (Seigneurin-Berny et al., 2006). Transports many heavy metals (Zn2+, Cu2+, Cd2+, Co2+), increasing heavy metal tolerance. Also transports Ca2+ (Km=370nM) in a thapsigargin-sensitive fashion (Moreno et al, 2008).

Accession Number:Q9M3H5
Protein Name:Hma1
Length:819
Molecular Weight:88189.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Plastid1 / Multi-pass membrane protein2
Substrate Ca2+, Co2+, Cd2+, Cu2+, Zn2+

Cross database links:

Genevestigator: Q9M3H5
HEGENOM: HBG507745
RefSeq: NP_195444.1   
Entrez Gene ID: 829881   
Pfam: PF00122    PF00702   
KEGG: ath:AT4G37270   

Gene Ontology

GO:0009706 C:chloroplast inner membrane
GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0008551 F:cadmium-exporting ATPase activity
GO:0015434 F:cadmium-transporting ATPase activity
GO:0005388 F:calcium-transporting ATPase activity
GO:0046872 F:metal ion binding
GO:0015633 F:zinc transporting ATPase activity
GO:0016463 F:zinc-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0006816 P:calcium ion transport
GO:0006878 P:cellular copper ion homeostasis
GO:0009642 P:response to light intensity
GO:0009636 P:response to toxin
GO:0055069 P:zinc ion homeostasis

References (2)

[1] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[2] “Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana.”  Ferro M.et.al.   12766230

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEPATLTRSS SLTRFPYRRG LSTLRLARVN SFSILPPKTL LRQKPLRISA SLNLPPRSIR 
61:	LRAVEDHHHD HHHDDEQDHH NHHHHHHQHG CCSVELKAES KPQKMLFGFA KAIGWVRLAN 
121:	YLREHLHLCC SAAAMFLAAA VCPYLAPEPY IKSLQNAFMI VGFPLVGVSA SLDALMDIAG 
181:	GKVNIHVLMA LAAFASVFMG NALEGGLLLA MFNLAHIAEE FFTSRSMVDV KELKESNPDS 
241:	ALLIEVHNGN VPNISDLSYK SVPVHSVEVG SYVLVGTGEI VPVDCEVYQG SATITIEHLT 
301:	GEVKPLEAKA GDRVPGGARN LDGRMIVKAT KAWNDSTLNK IVQLTEEAHS NKPKLQRWLD 
361:	EFGENYSKVV VVLSLAIAFL GPFLFKWPFL STAACRGSVY RALGLMVAAS PCALAVAPLA 
421:	YATAISSCAR KGILLKGAQV LDALASCHTI AFDKTGTLTT GGLTCKAIEP IYGHQGGTNS 
481:	SVITCCIPNC EKEALAVAAA MEKGTTHPIG RAVVDHSVGK DLPSIFVESF EYFPGRGLTA 
541:	TVNGVKTVAE ESRLRKASLG SIEFITSLFK SEDESKQIKD AVNASSYGKD FVHAALSVDQ 
601:	KVTLIHLEDQ PRPGVSGVIA ELKSWARLRV MMLTGDHDSS AWRVANAVGI TEVYCNLKPE 
661:	DKLNHVKNIA REAGGGLIMV GEGINDAPAL AAATVGIVLA QRASATAIAV ADILLLRDNI 
721:	TGVPFCVAKS RQTTSLVKQN VALALTSIFL AALPSVLGFV PLWLTVLLHE GGTLLVCLNS 
781:	VRGLNDPSWS WKQDIVHLIN KLRSQEPTSS SSNSLSSAH